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144-48-9

144-48-9 structure
144-48-9 structure
  • Name: Iodoacetamide
  • Chemical Name: 2-Iodoacetamide
  • CAS Number: 144-48-9
  • Molecular Formula: C2H4INO
  • Molecular Weight: 184.964
  • Catalog: Organic raw materials Amino compound Amide compound
  • Create Date: 2018-02-20 08:00:00
  • Modify Date: 2024-01-02 15:46:47
  • 2-Iodoacetamide (Iodoacetamide), an alkylating agent, is a commonly used agent for alkylation of cysteine during sample preparation for proteomics[1][2].
Name 2-Iodoacetamide
Synonyms MFCD00008028
carbamoylmethyl iodide
2-Iodo-acetamide
USAF D-1
Monoiodoacetamide
2-iodoacetamido
Acetamide, 2-iodo-
Iodoacetamide
ACETAMIDE,2-IODO
2-Iodoacetamide
Surauto
EINECS 205-630-1
Description 2-Iodoacetamide (Iodoacetamide), an alkylating agent, is a commonly used agent for alkylation of cysteine during sample preparation for proteomics[1][2].
Related Catalog
In Vivo 2-Iodoacetamide (2.0-10 mg; drinking; daily; 20-93 days) feeding always produces chronic deep ulcers in the secretory part of the rat stomach[2]. Animal Model: Sprague-Dawley rats[2] Dosage: 2.0-10 mg Administration: Drinking water, daily, for periods of 20 to 93 days Result: Produced gastritis which was further complicated by chronic ulceration in many of the test rats.
References

[1]. Peter G Hains, et al. The Impact of Commonly Used Alkylating Agents on Artifactual Peptide Modification. J Proteome Resq. 2017 Sep 1;16(9):3443-3447.

[2]. J J LALICH. Iodoacetamide induced gastric ulcers in rats. Proc Soc Exp Biol Med. 1962 Apr;109:905-8.
Density 2.3±0.1 g/cm3
Boiling Point 297.1±23.0 °C at 760 mmHg
Melting Point 92-95 °C(lit.)
Molecular Formula C2H4INO
Molecular Weight 184.964
Flash Point 133.5±22.6 °C
Exact Mass 184.933746
PSA 43.09000
LogP -0.19
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.602
Storage condition 2-8°C
Stability Stable, but light sensitive. Incompatible with strong oxidizing agents, strong bases, reducing agents, acids.
Water Solubility slightly soluble

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AC4200000
CHEMICAL NAME :
Acetamide, 2-iodo-
CAS REGISTRY NUMBER :
144-48-9
BEILSTEIN REFERENCE NO. :
1739080
LAST UPDATED :
199701
DATA ITEMS CITED :
9
MOLECULAR FORMULA :
C2-H4-I-N-O
MOLECULAR WEIGHT :
184.97
WISWESSER LINE NOTATION :
ZV1I

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
74 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
56 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1480 mg/kg/20W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Human Lymphocyte
DOSE/DURATION :
10 umol/L
REFERENCE :
STBIBN Studia Biophysica. (Akademie-Verlag GmbH, Postfach 1233, Berlin DDR-1086, Ger. Dem. Rep.) V.1- 1966- Volume(issue)/page/year: 50,97,1975 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4435 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 28 (estimated)
Symbol GHS06 GHS08
GHS06, GHS08
Signal Word Danger
Hazard Statements H301-H317-H334-H413
Precautionary Statements P261-P280-P301 + P310-P342 + P311
Personal Protective Equipment Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes T:Toxic;
Risk Phrases R25;R36/37/38;R43
Safety Phrases S22-S36/37-S45-S37/39-S26-S24
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS AC4200000
Packaging Group III
Hazard Class 6.1
HS Code 2924199090
54907-61-8 structure

54907-61-8

~66%

144-48-9 structure

144-48-9

Literature: Molecular Probes, Inc. Patent: US5274113 A1, 1993 ;
79-07-2 structure

79-07-2

~%

144-48-9 structure

144-48-9

Literature: Zeitschrift fuer Physikalische Chemie, Abteilung A: Chemische Thermodynamik, Kinetik, Elektrochemie, Eigenschaftslehre, , vol. 157, p. 249,254 Zeitschrift fuer Physikalische Chemie, Abteilung A: Chemische Thermodynamik, Kinetik, Elektrochemie, Eigenschaftslehre, , vol. 163, p. 38
624-75-9 structure

624-75-9

~%

144-48-9 structure

144-48-9

Literature: Synthesis, , p. 574 - 575
64-17-5 structure

64-17-5

79-07-2 structure

79-07-2

~%

144-48-9 structure

144-48-9

Literature: Chemische Berichte, , vol. 41, p. 2117 Chemische Berichte, , vol. 42, p. 2056
HS Code 2924199090
Summary 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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