70030-11-4

70030-11-4 structure

Name: 3-Hydroxyphenazepam
Chemical Name: 7-bromo-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one
CAS Number: 70030-11-4
Molecular Formula: C₁₅H₁₀BrClN₂O₂
Molecular Weight: 365.61
Catalog: Research Areas Neurological Disease
Create Date: 2018-06-20 11:04:35
Modify Date: 2024-01-02 18:37:57
3-Hydroxyphenazepam is an active metabolite of Cinazepam. Cinazepam is a GABAA receptor agonist. 3-Hydroxyphenazepam can inhibit synaptosomal transporter-mediated [3H]GABA uptake[1].

Name	7-bromo-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one
Synonyms	3-Hydroxyfenazepam 7-bromo-5-(2-chlorophenyl)-3-hydroxy-1,2-dihydro-3H-1,4-benzodiazepin-2-one 3-Oxyfenazepam 7-bromo-5-(2-chloro-phenyl)-3-hydroxy-1,3-dihydro-benzo[e][1,4]diazepin-2-one 7-Bromo-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-2H-1,4-benzodiazepin-2-one 3-Hydroxyphenazepam 2H-1,4-Benzodiazepin-2-one, 7-bromo-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-

Description	3-Hydroxyphenazepam is an active metabolite of Cinazepam. Cinazepam is a GABAA receptor agonist. 3-Hydroxyphenazepam can inhibit synaptosomal transporter-mediated [3H]GABA uptake[1].
Related Catalog	Research Areas >> Neurological Disease
References	[1]. Borisova T, et, al. GABAA receptor agonist cinazepam and its active metabolite 3-hydroxyphenazepam act differently at the presynaptic site. Eur Neuropsychopharmacol. 2021 Apr;45:39-51.

Density	1.7±0.1 g/cm3
Boiling Point	544.5±50.0 °C at 760 mmHg
Molecular Formula	C₁₅H₁₀BrClN₂O₂
Molecular Weight	365.61
Flash Point	283.1±30.1 °C
Exact Mass	363.961395
PSA	65.18000
LogP	2.46
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.712

51753-57-2

~38%

70030-11-4

Literature: Davidenko, T. I.; Zabolotskaya, N. N.; Milienko, N. P.; Andronati, S. A.; Kuznetsov, V. D.; Bogatskii, A. V. Doklady Chemistry, 1984 , vol. 278, p. 335 - 337 Dokl. Akad. Nauk SSSR Ser. Khim., 1984 , vol. 278, # 4 p. 878 - 881

51753-57-2

74077-27-3

74077-28-4

74077-25-1

Detail

Literature: Golovenko, N. Ya.; Zin'kovskii, V. G.; Bogatskii, A. V.; Sharbatyan, P. A.; Andronati, S. A. Pharmaceutical Chemistry Journal, 1980 , vol. 14, # 4 p. 208 - 213 Khimiko-Farmatsevticheskii Zhurnal, 1980 , vol. 14, # 4 p. 15 - 21

Precursor 1
51753-57-2
DownStream 0

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