81720-10-7

81720-10-7 structure

Name: dinophysistoxin-1
Chemical Name: 9,10-deepithio-9,10-didehydro-35-methyl-acanthifolicin
CAS Number: 81720-10-7
Molecular Formula: C₄₅H₇₀O₁₃
Molecular Weight: 819.02900
Catalog: Research Areas Cancer
Create Date: 2018-04-19 08:00:00
Modify Date: 2024-01-08 18:37:03
Dinophysistoxin 1 (DTX 1, 35-methylokadaic acid) is a causative agent of diarrhetic shellfish poisoning. Dinophysistoxin 1 exerts tumor-promoting activity, serves as a skin irritant as well[1].

Name	9,10-deepithio-9,10-didehydro-35-methyl-acanthifolicin
Synonyms	9,10-deepithio-9,10-didehydro-35-methyl-acanthifolici (35R)-9,45-Seco-10-demercapto-9,10-didehydro-35-methylacanthifolicin DINOPHYSISTOXIN-I 35-methylokadaicacid DTX1 OKADAIC ACID,35-METHYL Acanthifolicin,9,10-deepithio-9,10-didehydro-35-methyl DINOPHYSISTOXIN-1

Description	Dinophysistoxin 1 (DTX 1, 35-methylokadaic acid) is a causative agent of diarrhetic shellfish poisoning. Dinophysistoxin 1 exerts tumor-promoting activity, serves as a skin irritant as well[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	Dinophysistoxin 1 抑制特定的 [3H] 冈田酸与小鼠表皮颗粒部分的结合[1]。
In Vivo	Dinophysistoxin 1 (5 μg/mouse; 涂抹在背部; 每周 2 次, 共 30 周) 导致 100 μg 7,12-二甲基苯蒽 (DMBA) 处理组的荷瘤小鼠比例增加[1]。
References	[1]. Fujiki H, et al. Diarrhetic shellfish toxin, dinophysistoxin-1, is a potent tumor promoter on mouse skin. Jpn J Cancer Res. 1988 Oct;79(10):1089-93.

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors

REFERENCE :: JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB 211, 1000 AE Amsterdam, Netherlands) V.76- 1985- Volume(issue)/page/year: 79,1089,1988