Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Humantenmine
Price:
Purity: 96.5%
Stocking Period: 10 Day
Contact: Yang

BioBioPha
China
Product Name: Humantenmine
Price: ￥Inquiry/5mg
Purity: 96.0%
Stocking Period: 10 Day
Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Humantenmine
Price: ￥4800.0/5mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Liu jia

82354-38-9

82354-38-9 structure

82354-38-9 structure

Name: Humantenmine
Chemical Name: Humantenmine
CAS Number: 82354-38-9
Molecular Formula: C₁₉H₂₂N₂O₃
Molecular Weight: 326.390
Catalog: Natural product Alkaloid
Create Date: 2018-10-17 10:19:45
Modify Date: 2024-01-12 16:20:53
Humantenmine, a newalkaloid isolated from Gelsemium elegan Banth in China, has the potential for pain and rheumatic arthritis treatment[1][2].

Name	Humantenmine
Synonyms	(3S,3'R,3a'S,6'R,8a'S)-2'-ethyl-1-methoxy-3a',4',8',8a'-tetrahydro-3'H,6'H-spiro[indole-3,7'-[3,6]methanooxepino[4,3-b]pyrrol]-2(1H)-one Gelsedine, 4,20-didehydro- (1'R,3S,4'S,7'R,8'S)-6'-Ethyl-1-methoxyspiro[indole-3,2'-[10]oxa[5]azatricyclo[5.3.1.0]undec[5]en]-2(1H)-one

Description	Humantenmine, a newalkaloid isolated from Gelsemium elegan Banth in China, has the potential for pain and rheumatic arthritis treatment[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
In Vitro	Humantenmine (HMT) decreases the 14-day survival rate of the mice to 17% after they are intragastrically treated with HMT, along with hepatic injury and increasing alanine aminotransferase (ALT)/aspartate aminotransferase (AST) levels. CYP3A4/5 mediates the metabolism and detoxification of HMT[1][2].
References	[1]. Kun Yang, et al. Development and In-House Validation of a Sensitive LC-MS/MS Method for Simultaneous Quantification of Gelsemine, Koumine and Humantenmine in Porcine Plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Feb 15;1076:54-60. [2]. Rongjin Sun, et al. CYP3A4/5 Mediates the Metabolic Detoxification of Humantenmine, a Highly Toxic Alkaloid From Gelsemium Elegans Benth. J Appl Toxicol. 2019 Sep;39(9):1283-1292.

Density	1.4±0.1 g/cm3
Boiling Point	463.6±55.0 °C at 760 mmHg
Molecular Formula	C₁₉H₂₂N₂O₃
Molecular Weight	326.390
Flash Point	234.2±31.5 °C
Exact Mass	326.163055
PSA	51.13000
LogP	3.68
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.712

Hazard Codes	Xi