5523-37-5

5523-37-5 structure

Name: (15S,16E)-16,17,20,21-Tetradehydro-16-formyl-18,19-secoyohimban-19-oic acid methyl ester
Chemical Name: methyl (2S)-2-[(E)-1-oxobut-2-en-2-yl]-1,2,6,7,12,12b-hexahydroindolo[2,3-a]quinolizine-3-carboxylate
CAS Number: 5523-37-5
Molecular Formula: C₂₁H₂₂N₂O₃
Molecular Weight: 350.41
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2017-10-27 19:43:02
Modify Date: 2024-02-08 19:00:35
Vallesiachotamine, a known monoterpene indole alkaloid, possesses anti-tumor activity[1].

Name	methyl (2S)-2-[(E)-1-oxobut-2-en-2-yl]-1,2,6,7,12,12b-hexahydroindolo[2,3-a]quinolizine-3-carboxylate
Synonyms	18,19-Secoyohimban-19-oic acid,16,17,20,21-tetradehydro-16-formyl-,methyl ester,(15beta,16E)

Description	Vallesiachotamine, a known monoterpene indole alkaloid, possesses anti-tumor activity[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
In Vitro	Vallesiachotamine induces G0/G1 arrest and increased the proportion of sub-G1 hypodiploid cells (at 11 μM and 22 μM) and this effect is not dependent on time of incubation. Vallesiachotamine acts by promoting G0/G1 cell cycle arrest, apoptosis and necrosis[1].
References	[1]. Paula R O Soares, et al. In vitro antiproliferative effects of the indole alkaloid vallesiachotamine on human melanoma cells. Paula R O Soares. 2012 Mar;35(3):565-71.