287194-40-5

287194-40-5 structure

Name: (-)-DHMEQ
Chemical Name: 2-hydroxy-N-[(1S,2S,6S)-2-hydroxy-5-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]benzamide
CAS Number: 287194-40-5
Molecular Formula: C₁₃H₁₁NO₅
Molecular Weight: 261.23000
Catalog: Signaling Pathways NF-κB NF-κB
Create Date: 2016-12-22 05:01:38
Modify Date: 2024-01-10 12:22:34
(–)-DHMEQ is a potent NF-κB inhibitor.

Name	2-hydroxy-N-[(1S,2S,6S)-2-hydroxy-5-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]benzamide
Synonyms	(-)-DHM2EQ DHMEQ Dehydroxymethylepoxyquinomicin 2-Hydroxy-N-((1S,2S,6S)-2-hydroxy-5-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl)benzamide (-)-DHMEQ

Description	(–)-DHMEQ is a potent NF-κB inhibitor.
Related Catalog	Signaling Pathways >> NF-κB >> NF-κB Research Areas >> Cancer
Target	RelA RelB
In Vitro	(–)-DHMEQ binds to cysteine 38 of RelA and cysteine 144 of RelB. (−)-DHMEQ at concentrations greater than 25 µM inhibits the LTβ-induced nuclear translocation of FLAG-RelB WT, whereas the inhibitory effect of (–)-DHMEQ on the nuclear translocation of FLAG-RelB (C144S) became weaker at the same concentrations[1].
Cell Assay	A549 cells transfectants stably expressing RelB WT and RelB (C144S) are preincubated with various concentrations of (-)-DHMEQ (1, 5, 10, 25, and 50 μM) for 1h and then incubated with or without LTβ (25 ng/mL) for 2 h in the presence or absence of (-)-DHMEQ.Cytoplasmic and nuclear extracts are analyzed by Western blotting[1].
References	[1]. Quach HT, et al. Eudesmane-Type Sesquiterpene Lactones Inhibit Nuclear Translocation of the Nuclear Factor κB Subunit RelB in Response to a Lymphotoxin β Stimulation. Biol Pharm Bull. 2017;40(10):1669-1677. [2]. Kang J, et al. Exposure to a combination of formaldehyde and DINP aggravated asthma-like pathology through oxidative stress and NF-κB activation. Toxicology. 2018 May 14;404-405:49-58.