301297-45-0

301297-45-0 structure

Name: IQP-0528
Chemical Name: 1-(cyclopropylmethyl)-6-(3,5-dimethylbenzoyl)-5-propan-2-ylpyrimidine-2,4-dione
CAS Number: 301297-45-0
Molecular Formula: C₂₀H₂₄N₂O₃
Molecular Weight: 340.42
Catalog: Signaling Pathways Anti-infection HIV
Create Date: 2016-01-03 14:18:30
Modify Date: 2024-01-06 14:31:40
IQP-0528 is a highly potent nonnucleoside reverse transcriptase inhibitor (NNRTI). IQP-0528 shows nanomolar activity against both HIV-1 and HIV-2, with an HIV-1 EC50 of 0.2 nM and an HIV-2 EC50 of 100 nM[1].

Name	1-(cyclopropylmethyl)-6-(3,5-dimethylbenzoyl)-5-propan-2-ylpyrimidine-2,4-dione
Synonyms	1-(cyclopropylmethyl)-6-(3,5-dimethylbenzoyl)-5-(propan-2-yl)pyrimidine-2,4(1h,3h)-dione 2,4(1H,3H)-Pyrimidinedione,1-(cyclopropylmethyl)-6-(3,5-dimethylbenzoyl)-5-isopropyl UNII-1Y42TZL33O IQP-528 IQP-0528

Description	IQP-0528 is a highly potent nonnucleoside reverse transcriptase inhibitor (NNRTI). IQP-0528 shows nanomolar activity against both HIV-1 and HIV-2, with an HIV-1 EC50 of 0.2 nM and an HIV-2 EC50 of 100 nM[1].
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection Signaling Pathways >> Anti-infection >> Reverse Transcriptase
References	[1]. Su JT, et al. A Dose Ranging Pharmacokinetic Evaluation of IQP-0528 Released from Intravaginal Rings in Non-Human Primates. Pharm Res. 2017;34(10):2163-2171.