ShangHai DC Chemicals Co.,Ltd
China
Product Name: Benzyl selenocyanate
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

DC Chemicals Limited
China
Product Name: Benzyl selenocyanate
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Selenocyanic acid, benzyl ester
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

4671-93-6

4671-93-6 structure

Name: Benzyl selenocyanate
Chemical Name: benzyl selenocyanate
CAS Number: 4671-93-6
Molecular Formula: C₈H₇NSe
Molecular Weight: 196.10800
Catalog: Signaling Pathways Epigenetics DNA Methyltransferase
Create Date: 2016-10-14 04:38:01
Modify Date: 2024-01-11 18:54:24
Benzyl selenocyanate is a chemopreventive agent for various chemically induced tumors in animal models at both the initiation and postinitiation stages. Benzyl selenocyanate is an inhibitor of DNA (cytosine-5)-methyltransferase (Mtase), with an with an IC50 of 8.4 µM[1].

Name	benzyl selenocyanate
Synonyms	Selenocyansaeure-benzylester Benzylselenocyanat C8H7NSe benzylselenocyanate phenylmethaneselenenyl cyanide Selenocyanic acid,benzyl ester

Description	Benzyl selenocyanate is a chemopreventive agent for various chemically induced tumors in animal models at both the initiation and postinitiation stages. Benzyl selenocyanate is an inhibitor of DNA (cytosine-5)-methyltransferase (Mtase), with an with an IC50 of 8.4 µM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> DNA Methyltransferase
Target	Mtase[1]
In Vitro	Benzyl selenocyanate inhibits the activity of DNA (cytosine-5)-methyltransferase (Mtase) in a concentration-dependent manner[1].
References	[1]. E S Fiala, er al. Inhibition of DNA cytosine methyltransferase by chemopreventive selenium compounds, determined by an improved assay for DNA cytosine methyltransferase and DNA cytosine methylation. Carcinogenesis. 1998 Apr;19(4):597-604.

Boiling Point	276.7ºC at 760 mmHg
Molecular Formula	C₈H₇NSe
Molecular Weight	196.10800
Flash Point	121.2ºC
Exact Mass	196.97400
PSA	23.79000
LogP	1.63828

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VT0795000

CHEMICAL NAME :: Selenocyanic acid, benzyl ester

CAS REGISTRY NUMBER :: 4671-93-6

BEILSTEIN REFERENCE NO. :: 1932614

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C8-H7-N-Se

MOLECULAR WEIGHT :: 196.12

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 98500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 45500 ug/kg/13W-C

TOXIC EFFECTS :: Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - changes in testicular weight

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 227 nmol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 232,227,1990

100-39-0

3425-46-5

~99%

4671-93-6

Literature: Clarembeau, M.; Cravador, A.; Dumont, W.; Hevesi, L; Krief, A.; et al. Tetrahedron, 1985 , vol. 41, # 21 p. 4793 - 4812

3425-46-5

100-44-7

~84%

4671-93-6

Literature: Otsubo, Tetsuo; Ogura, Fumio; Yamaguchi, Hachiro Synthetic Communications, 1980 , vol. 10, # 8 p. 595 - 602

1482-82-2

75-05-8

~49%

4671-93-6

Literature: Degrand, Chantal; Prest, Rita; Nour, Mohamed Phosphorus and Sulfur and the Related Elements, 1988 , vol. 38, p. 201 - 210

56634-64-1

4671-93-6

Literature: Tamagaki,S. et al. Bulletin of the Chemical Society of Japan, 1978 , vol. 51, p. 333 - 334

100-44-7

4671-93-6

Literature: Degrand, Chantal; Prest, Rita; Nour, Mohamed Phosphorus and Sulfur and the Related Elements, 1988 , vol. 38, p. 201 - 210

25862-08-2

670-54-2

4671-93-6

Literature: Tamagaki,S. et al. Bulletin of the Chemical Society of Japan, 1977 , vol. 50, # 6 p. 1641 - 1642

5487-13-8

100-39-0

4671-93-6

Literature: Uemura,S. et al. Bulletin of the Chemical Society of Japan, 1978 , vol. 51, p. 1818 - 1820

Precursor 9
100-39-0 3425-46-5 100-44-7 1482-82-2
75-05-8 56634-64-1 25862-08-2 670-54-2
5487-13-8
DownStream 7
7677-24-9 186047-38-1 100-44-7 1482-82-2
1842-38-2 83293-39-4 5925-78-0

4671-93-6	85728-58-1
1218791-42-4	78385-37-2
1217786-42-9	15201-70-4
1373028-75-1	1217693-52-1
1207853-10-8	1187928-18-2
1039968-13-2	2386047-15-8
949250-03-7	1090923-26-4
1431505-25-7	31527-64-7
1018051-31-4	896862-71-8
1158682-62-2	1037131-07-9