23749-58-8

23749-58-8 structure

Name: 7H-Benzimidazo[2,1-a]benzo[de]isoquinolin-7-one
Chemical Name: Yellow-green 490RT
CAS Number: 23749-58-8
Molecular Formula: C₁₈H₁₀N₂O
Molecular Weight: 270.28
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2018-12-30 23:44:29
Modify Date: 2024-01-06 11:21:41
AHR agonist 3 is an aryl hydrocarbon receptor (AhR) agonist, that can induces cell cycle arrest or apoptosis via activation of tumor-suppressive transcriptional programs. AHR agonist 3 inhibits triple-negative breast cancer (TNBC) stem cell growth via AhR while exhibits minimal cytotoxicity against normal human primary cells and can be used for cancer research[1].

Name	Yellow-green 490RT
Synonyms	7-H-benzimidazo<2,1-a>benzo<d,e>isoquinolin-7-one Luminogren EINECS 245-865-7 Luminor 2 12H-Naphtho<1',8',8'a-3,4,5>pyrido<1,2-a>benzimidazole-12-one Luminor Yellow Green 490RT Luminophor 2 Naphthoylenebenzimidazole solvent yellow 184

Description	AHR agonist 3 is an aryl hydrocarbon receptor (AhR) agonist, that can induces cell cycle arrest or apoptosis via activation of tumor-suppressive transcriptional programs. AHR agonist 3 inhibits triple-negative breast cancer (TNBC) stem cell growth via AhR while exhibits minimal cytotoxicity against normal human primary cells and can be used for cancer research[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> Aryl Hydrocarbon Receptor
References	[1]. Elson DJ, et.al. Induction of Aryl Hydrocarbon Receptor-Mediated Cancer Cell-Selective Apoptosis in Triple-Negative Breast Cancer Cells by a High-Affinity Benzimidazoisoquinoline. ACS Pharmacol Transl Sci. 2023 Jun 7;6(7):1028-1042.

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - hemorrhage Behavioral - muscle weakness Gastrointestinal - other changes

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(1),89,1986 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TOXIC EFFECTS :: Liver - liver function tests impaired Kidney, Ureter, Bladder - other changes Related to Chronic Data - death

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(1),89,1986

HS Code	2933990090

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%