92264-81-8
92264-81-8 structure
- Name: Hydroxybupropion
- Chemical Name: Hydroxybupropione
- CAS Number: 92264-81-8
- Molecular Formula: C13H18ClNO2
- Molecular Weight: 255.74100
- Catalog: analytical chemistry Standard standard material
- Create Date: 2018-08-17 12:51:28
- Modify Date: 2024-01-02 18:18:26
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Hydroxybupropion is the major active metabolite of Bupropion. Hydroxybupropion is metabolized by CYP2B6.Bupropion is an atypical antidepressant and smoking-cessation agent. Hydroxybupropion inhibits norepinephrine uptake with an IC50 value of 1.7 μM. Hydroxybupropion is also a nACh receptor antagonis tis more potent than Bupropion[1] .
| Name | Hydroxybupropione |
|---|---|
| Synonyms | Hydroxybupropion |
| Description | Hydroxybupropion is the major active metabolite of Bupropion. Hydroxybupropion is metabolized by CYP2B6.Bupropion is an atypical antidepressant and smoking-cessation agent. Hydroxybupropion inhibits norepinephrine uptake with an IC50 value of 1.7 μM. Hydroxybupropion is also a nACh receptor antagonis tis more potent than Bupropion[1] . |
|---|---|
| Related Catalog | |
| Target |
IC50: 1.7 μM (Norepinephrine uptake)[1] nACh receptor[1] |
| References |
| Density | 1.15 g/cm3 |
|---|---|
| Boiling Point | 393.9ºC at 760 mmHg |
| Melting Point | 121-123ºC |
| Molecular Formula | C13H18ClNO2 |
| Molecular Weight | 255.74100 |
| Flash Point | 192ºC |
| Exact Mass | 255.10300 |
| PSA | 49.33000 |
| LogP | 2.66260 |
| Storage condition | ?20°C |
| Symbol |
GHS02, GHS07 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H225-H302 + H312 + H332-H319 |
| Precautionary Statements | P210-P261-P302 + P352 + P312-P304 + P340 + P312-P337 + P313-P403 + P235 |
| Hazard Codes | F,Xn |
| Risk Phrases | 11-20/21/22-36 |
| Safety Phrases | 16-36/37 |
| RIDADR | UN 1648 3 / PGII |
| HS Code | 2922509090 |
|
~55%
92264-81-8 |
| Literature: SOSEI R and D LTD. Patent: WO2007/102008 A1, 2007 ; Location in patent: Page/Page column 8 ; |
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92264-81-8 |
| Literature: European Journal of Clinical Pharmacology, , vol. 59, # 5-6 p. 429 - 442 |
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92264-81-8 |
| Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 7, # 1 p. 1 - 6 |
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92264-81-8 |
| Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 7, # 1 p. 1 - 6 |
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92264-81-8 |
| Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 7, # 1 p. 1 - 6 |
| Precursor 6 | |
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| DownStream 0 | |
| HS Code | 2922509090 |
|---|---|
| Summary | 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |