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5995-86-8

5995-86-8 structure
5995-86-8 structure
  • Name: Gallic acid hydrate
  • Chemical Name: Gallic acid monohydrate
  • CAS Number: 5995-86-8
  • Molecular Formula: C7H8O6
  • Molecular Weight: 188.135
  • Catalog: API Other chemicals Health and epidemic prevention drugs
  • Create Date: 2018-03-14 08:00:00
  • Modify Date: 2024-01-02 10:57:06
  • Gallic acid (3,4,5-Trihydroxybenzoic acid) hydrate is a natural polyhydroxyphenolic compound and an free radical scavenger to inhibit cyclooxygenase-2 (COX-2)[1]. Gallic acid hydrate has various activities, such as antimicrobial, antioxidant, antimicrobial, anti-inflammatory, and anticance activities[2].
Name Gallic acid monohydrate
Synonyms Benzoic acid, 3,4,5-trihydroxy-, hydrate (1:1)
Gallic acid monohydrate
3,4,5-Trihydroxybenzoic acid hydrate (1:1)
MFCD00002510
3,4,5-trihydroxybenzoic acid,hydrate
EINECS 205-749-9
Description Gallic acid (3,4,5-Trihydroxybenzoic acid) hydrate is a natural polyhydroxyphenolic compound and an free radical scavenger to inhibit cyclooxygenase-2 (COX-2)[1]. Gallic acid hydrate has various activities, such as antimicrobial, antioxidant, antimicrobial, anti-inflammatory, and anticance activities[2].
Related Catalog
Target

COX-2

Human Endogenous Metabolite

In Vitro Gallic acid is an antioxidant which can inhibit both COX-2[1]. After 18 h treatment with Gallic acid, the number of viable neutrophils is dramatically decreased from 40.3% to 27.7%, highly comparable with 26.4% for untreated neutrophils. Gallic acid fails to attenuate isoproterenol-induced myocytolysis[3].
In Vivo The food intake (2.6±0.08 g/day, p=0.69) and the body weight (2.5±0.69 g, p=0.76) of the Gallic acid group do not differ significantly from those of the control group (food intake; 2.41±0.14 g/day and the body weight; 2.83±0.84 g/day). The blood glucose tolerance in the Gallic acid group is significantly improved after 2 weeks of treatment. The blood glucose tolerance of the Gallic acid group after a treatment period of 2 weeks is also significantly better than that of the control group at 90 and 120 min ( p<0.05). The serum triglyceride concentration in the Gallic acid group (0.67±0.03 mM, p<0.05) is significantly reduced relative to that of the control group (1.08±0.20 mM). The total cholesterol concentration is similar in the control (3.19±0.27 mM) and Gallic acid (3.01±0.18 mM) groups[2].
References

[1]. Amaravani M, et al. COX-2 structural analysis and docking studies with gallic acid structural analogues. Springerplus. 2012 Dec;1(1):58.

[2]. Bak EJ, et al. Gallic acid improves glucose tolerance and triglyceride concentration in diet-induced obesity mice. Scand J Clin Lab Invest. 2013 Dec;73(8):607-14.

[3]. Cheng Y, et al. Plant Natural Products Calycosin and Gallic Acid Synergistically Attenuate Neutrophil Infiltration and Subsequent Injury in Isoproterenol-Induced Myocardial Infarction: A Possible Role for Leukotriene B4 12-Hydroxydehydrogenase? Oxid Med Cell Longev. 2015;2015:434052.

[4]. Felipe Hugo Alencar Fernandes, et al. Gallic Acid: Review of the Methods of Determination and Quantification. Crit Rev Anal Chem
Density 1.694
Boiling Point 596.6ºC at 760 mmHg
Melting Point 252 °C (dec.)(lit.)
Molecular Formula C7H8O6
Molecular Weight 188.135
Flash Point 250 °C
Exact Mass 188.032089
PSA 107.22000
LogP 0.43730
Water Solubility 15 g/l (20 ºC)
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S36-S24/25
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS LW7525000
HS Code 2918290000
Precursor  0

DownStream  1

HS Code 2918290000
Summary HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

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