Shanghai Nianxing Industrial Co., Ltd
China
Product Name: CHAPS
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Purity: 99.0%
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: CHAPS
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Purity: 98.0%
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DC Chemicals Limited
China
Product Name: CHAPS
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 3-((3-Cholamidopropyl)dimethylammonium)-1-propanesulfonate
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: TIANFU-CHEM_3-((3-Cholamidopropyl)dimethylammonium)-1-propanesulfonate 75621-03-3
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Purity: 99.0%
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75621-03-3

75621-03-3 structure

Name: CHAPS
Chemical Name: 3-((3-Cholamidopropyl)dimethylammonium)-1-propanesulfonate
CAS Number: 75621-03-3
Molecular Formula: C₃₂H₅₈N₂O₇S
Molecular Weight: 614.877
Catalog: Organic raw materials Amino compound Sulfonic acid amino compound
Create Date: 2018-12-27 09:36:34
Modify Date: 2024-01-03 11:29:02
CHAPS is a zwitterionic nondenaturing detergent for solubilizing membrane proteins. Target: CHAPS is often used as a detergent in the solubilization and purification of membrane proteins for several advantageous reasons.CHAPS detergent is non-denaturing to membrane proteins, can solubilize proteins, disaggregate protein-protein interactions and is electrically neutral. CHAPS is also useful in ion exchange chromatography and isoelectric focusing as it is zwitterionic and does not exhibit a net charge between pH 2 to 12. The critical micelle concentration of CHAPS is 6-10mM.

Name	3-((3-Cholamidopropyl)dimethylammonium)-1-propanesulfonate
Synonyms	3-[Dimethyl(3-{[(3α,7α,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino}propyl)ammonio]propane-1-sulfonate CHAPS,HighPurity 3-[Dimethyl(3-{[(3α,7α,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino}propyl)ammonio]-1-propanesulfonate 1-Propanaminium, N,N-dimethyl-3-sulfo-N-[3-[[(3α,7α,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino]propyl]-, inner salt 3-{Dimethyl[3-({(4R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl}amino)propyl]ammonio}-1-propanesulfonate CHAPS Solution CHAPS ELECTROPHORESIS REAGENT 1-Propanaminium, N,N-dimethyl-3-sulfo-N-[3-[[(3α,5β,7α,8ξ,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino]propyl]-, inner salt MFCD00012116 CHAPS-SOL GRADE 3-[Dimethyl(3-{[(3α,5β,7α,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino}propyl)ammonio]-1-propanesulfonate CHAPS 3-[Dimethyl(3-{[(3α,5β,7α,8ξ,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino}propyl)ammonio]propan-1-sulfonat 1-Propanaminium, N,N-dimethyl-3-sulfo-N-[3-[[(3α,5β,7α,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino]propyl]-, inner salt 3-[Dimethyl(3-{[(3α,5β,7α,8ξ,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino}propyl)ammonio]-1-propanesulfonate 3-[Dimethyl(3-{[(3α,5β,7α,8ξ,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino}propyl)ammonio]propane-1-sulfonate CHAPS extrapure TREND N,N-Dimethyl-N-(3-sulfopropyl)-3-[[(3a,5b,7a,12a)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino]-1-propanaminium Hydroxide Inner Salt

Description	CHAPS is a zwitterionic nondenaturing detergent for solubilizing membrane proteins. Target: CHAPS is often used as a detergent in the solubilization and purification of membrane proteins for several advantageous reasons.CHAPS detergent is non-denaturing to membrane proteins, can solubilize proteins, disaggregate protein-protein interactions and is electrically neutral. CHAPS is also useful in ion exchange chromatography and isoelectric focusing as it is zwitterionic and does not exhibit a net charge between pH 2 to 12. The critical micelle concentration of CHAPS is 6-10mM.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Others
References	[1]. Ofri D, Ritter AM, Liu YF et al. Characterization of solubilized opioid receptors: reconstitution and uncoupling of guanine nucleotide-sensitive agonist binding. J Neurochem. 1992 Feb;58(2):628-35. [2]. Banerjee P, Joo JB, Buse JT, Dawson G. Differential solubilization of lipids along with membrane proteins by different classes of detergents. Chem Phys Lipids. 1995 Aug 1;77(1):65-78. [3]. Pasquali C, Fialka I, Huber LA. Preparative two-dimensional gel electrophoresis of membrane proteins. Electrophoresis. 1997 Dec;18(14):2573-81. [4]. Menshikova I, Menshikov E, Filenko N, Lyubchenko YL. Nucleosomes structure and dynamics: effect of CHAPS. Int J Biochem Mol Biol. 2011;2(2):129-137. [5]. Krofli? A, Sarac B, Be?ter-Roga? M. Thermodynamic characterization of 3-[(3-cholamidopropyl)-dimethylammonium]-1-propanesulfonate (CHAPS) micellization using isothermal titration calorimetry: temperature, salt, and pH dependence. Langmuir. 2012 Jul 17;28(

Density	1.01 g/mL at 20ºC
Melting Point	156-158ºC
Molecular Formula	C₃₂H₅₈N₂O₇S
Molecular Weight	614.877
Exact Mass	614.396484
PSA	155.37000
LogP	-4.32
Index of Refraction	1.6900 (estimate)
Storage condition	2-8°C
Stability	Moisture Sensitive: Hydroscopic
Water Solubility	H2O: 50 mg/mL at 20 °C, clear, colorless \| Soluble in water (10 mg/ml). Soluble in DMF and hot methanol.

Personal Protective Equipment	Eyeshields;Gloves
Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2934999090

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%