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83-07-8

83-07-8 structure
83-07-8 structure

Name 4-aminoantipyrine
Synonyms 4-amino-1,5-dimethyl-2-phenylpyrazol-3-one
EINECS 201-452-3
4-Aminoantipyrine
MFCD00003145
Description Ampyrone is a reagent for glucose determination in the presence of peroxidase and phenol.
Related Catalog
Target

COX

References

[1]. Berno CR, et al. 4-Aminoantipyrine reduces toxic and genotoxic effects of doxorubicin, cisplatin, and cyclophosphamide in male mice. Mutat Res Genet Toxicol Environ Mutagen. 2016 Jul;805:19-24.

Density 1.2±0.1 g/cm3
Boiling Point 309.0±45.0 °C at 760 mmHg
Melting Point 105-110 °C(lit.)
Molecular Formula C11H13N3O
Molecular Weight 203.240
Flash Point 140.7±28.7 °C
Exact Mass 203.105865
PSA 52.95000
LogP -0.40
Vapour Pressure 0.0±0.7 mmHg at 25°C
Index of Refraction 1.607
Storage condition Store at RT.
Stability Stable. May be light sensitive.
Water Solubility ca. 500 g/L (20 ºC)

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CD2480000
CHEMICAL NAME :
Antipyrine, 4-amino-
CAS REGISTRY NUMBER :
83-07-8
BEILSTEIN REFERENCE NO. :
0181635
LAST UPDATED :
199710
DATA ITEMS CITED :
11
MOLECULAR FORMULA :
C11-H13-N3-O
MOLECULAR WEIGHT :
203.27
WISWESSER LINE NOTATION :
T5NNVJ A1 BR& DZ E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
270 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

MUTATION DATA

TYPE OF TEST :
DNA repair
TEST SYSTEM :
Bacteria - Escherichia coli
DOSE/DURATION :
312 ug/well
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 133,161,1984 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82277 No. of Facilities: 114 (estimated) No. of Industries: 4 No. of Occupations: 3 No. of Employees: 1130 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82277 No. of Facilities: 1080 (estimated) No. of Industries: 5 No. of Occupations: 7 No. of Employees: 12808 (estimated) No. of Female Employees: 9012 (estimated)
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Precautionary Statements P301 + P312 + P330
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn:Harmful
Risk Phrases R22;R36/37/38
Safety Phrases S26-S36-S36/37/39
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS CD2480000
HS Code 29331190
HS Code 2933199090
Summary 2933199090. other compounds containing an unfused pyrazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%