179237-49-1

179237-49-1 structure

Name: 3-Hydroxy Midostaurin
Chemical Name: cgp52421
CAS Number: 179237-49-1
Molecular Formula: C₃₅H₃₀N₄O₅
Molecular Weight: 586.63600
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK FLT3
Create Date: 2017-02-14 05:24:17
Modify Date: 2024-01-02 12:12:01
3-Hydroxy Midostaurin (CGP 52421), a metabolite of PKC412, effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50s of approximately 132 nM and 9.8 μM in culture medium and plasma, respectively. 3-Hydroxy Midostaurin is less selective but more cytotoxic than PKC412[1].

Name	cgp52421

Description	3-Hydroxy Midostaurin (CGP 52421), a metabolite of PKC412, effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50s of approximately 132 nM and 9.8 μM in culture medium and plasma, respectively. 3-Hydroxy Midostaurin is less selective but more cytotoxic than PKC412[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FLT3
Target	IC50: 132 nM (FLT3 in culture medium) and 9.8 μM (FLT3 in plasma)[1]
In Vitro	CGP52421 (200, 400, 600, 800, 1000 nM) is more cytotoxic than PKC412 over the dose range 100 to 500 nM[1].
References	[1]. Levis M, et al. Plasma inhibitory activity (PIA): a pharmacodynamic assay reveals insights into the basis for cytotoxic response to FLT3 inhibitors. Blood. 2006 Nov 15;108(10):3477-83.