Top Suppliers:I want be here
  • DC Chemicals Limited
  • China
  • Product Name: Qc1
  • Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao
Related CAS#:
403718-45-6 744209-37-8
1613410-75-5 88561-91-5
1359705-87-5 950912-80-8
215454-25-4 168003-06-3
1041423-26-0 470484-70-9

403718-45-6

403718-45-6 structure
403718-45-6 structure
  • Name: Qc 1
  • Chemical Name: N-Benzyl-4-oxo-2-thioxo-3-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydro-7-quinazolinecarboxamide
  • CAS Number: 403718-45-6
  • Molecular Formula: C23H16F3N3O2S
  • Molecular Weight: 455.452
  • Catalog: Research Areas Metabolic Disease
  • Create Date: 2017-06-13 11:26:15
  • Modify Date: 2024-04-09 11:53:19
  • Qc1 is a reversible and noncompetitive threonine dehydrogenase (TDH) inhibitor. Qc1 can be used for the research of Metabolic disease[1][2].
Name N-Benzyl-4-oxo-2-thioxo-3-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydro-7-quinazolinecarboxamide
Synonyms N-Benzyl-4-oxo-2-thioxo-3-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydro-7-quinazolinecarboxamide
7-Quinazolinecarboxamide, 1,2,3,4-tetrahydro-4-oxo-N-(phenylmethyl)-2-thioxo-3-[3-(trifluoromethyl)phenyl]-
Description Qc1 is a reversible and noncompetitive threonine dehydrogenase (TDH) inhibitor. Qc1 can be used for the research of Metabolic disease[1][2].
Related Catalog
Target

TDH[1]

In Vitro Qc1 (10 μM; 2~24 hours; ES cells) shows that a substantial fraction of the total LC3 protein is in the LC3-I (cytoplasmic) form. After 16 h of TDH inhibition, most LC3 is converted to the LC3-II (lipid-modified) form, indicative of increased autophagic activity[2]. . Qc1 blocks the charging of tetrahydrofolate. Qc1 prevents threonine dehydrogenase from catabolizing threonine into acetyl-CoA and glycine[1][2].
References

[1]. Wang J, et al. Metabolic specialization of mouse embryonic stem cells. Cold Spring Harb Symp Quant Biol. 2011;76:183-193.

[2]. Alexander PB, et al. Targeted killing of a mammalian cell based upon its specialized metabolic state. Proc Natl Acad Sci U S A. 2011;108(38):15828-15833.
Density 1.5±0.1 g/cm3
Molecular Formula C23H16F3N3O2S
Molecular Weight 455.452
Exact Mass 455.091522
PSA 98.98000
LogP 4.34
Index of Refraction 1.682
RIDADR NONH for all modes of transport

Chemsrc provides CAS#:403718-45-6 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 403718-45-6 | Chemsrc address: https://www.chemsrc.com/en/baike/829117.html

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved