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456-59-7

456-59-7 structure
456-59-7 structure
  • Name: cyclandelate
  • Chemical Name: cyclandelate
  • CAS Number: 456-59-7
  • Molecular Formula: C17H24O3
  • Molecular Weight: 276.371
  • Catalog: Pharmaceutical intermediate Heterocyclic compound Pyrimidine compound Hydroxypyrimidine
  • Create Date: 2018-09-22 12:02:18
  • Modify Date: 2024-01-05 13:21:11
  • Cyclandelate is a vasodilator used in the treatment of claudication, arteriosclerosis, and Raynaud's disease. It is also used to treat nighttime leg cramps, and has been investigated for its effect against migraine.
Name cyclandelate
Synonyms cyclospasmol
Capilan
Benzeneacetic acid, α-hydroxy-, 3,3,5-trimethylcyclohexyl ester
Lejopan
3,3,5-Trimethylcyclohexanol a-Phenyl-a-hydroxyacetate
cyclandelate
bs572
EINECS 207-271-6
3,3,5-Trimethylcyclohexyl hydroxy(phenyl)acetate
mandelic acid
Mandelsaeure-<3,5,5-trimethyl-cyclohexylester>
a-Hydroxybenzeneacetic Acid 3,3,5-Trimethylcyclohexyl Ester
Novodil
3.3.5-Trimethylcyclohexyl-mandelat
Anaspat
Dilatan
Sepyron
Mandelic Acid 3,3,5-Trimethylcyclohexyl Ester
UNII:4139O1OAY2
Natil
Cydel
3,3,5-TriMethylcyclohexyl Mandelate
Description Cyclandelate is a vasodilator used in the treatment of claudication, arteriosclerosis, and Raynaud's disease. It is also used to treat nighttime leg cramps, and has been investigated for its effect against migraine.
Related Catalog
Density 1.1±0.1 g/cm3
Boiling Point 380.1±22.0 °C at 760 mmHg
Melting Point 55.0-56.5°
Molecular Formula C17H24O3
Molecular Weight 276.371
Flash Point 150.1±15.1 °C
Exact Mass 276.172546
PSA 46.53000
LogP 4.49
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.533

CHEMICAL IDENTIFICATION

RTECS NUMBER :
OO8200000
CHEMICAL NAME :
Mandelic acid, 3,3,5-trimethylcyclohexyl ester
CAS REGISTRY NUMBER :
456-59-7
LAST UPDATED :
199701
DATA ITEMS CITED :
9
MOLECULAR FORMULA :
C17-H24-O3
MOLECULAR WEIGHT :
276.41
WISWESSER LINE NOTATION :
L6TJ A1 A1 C1 EOVYQR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,310,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2570 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Lungs, Thorax, or Respiration - other changes
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 105,145,1956
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,310,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3780 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Lungs, Thorax, or Respiration - other changes
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 105,145,1956
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Lungs, Thorax, or Respiration - other changes
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 105,145,1956
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
3950 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Lungs, Thorax, or Respiration - other changes
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 105,145,1956
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
2480 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Lungs, Thorax, or Respiration - other changes
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 105,145,1956 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4828 No. of Facilities: 42 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 457 (estimated) No. of Female Employees: 234 (estimated)
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H319
Precautionary Statements P305 + P351 + P338
Hazard Codes Xi
RIDADR NONH for all modes of transport
RTECS OO8200000
HS Code 2942000000
HS Code 2918199090
Summary 2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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