545-48-2

545-48-2 structure

Name: Erythrodiol
Chemical Name: erythrodiol
CAS Number: 545-48-2
Molecular Formula: C₃₀H₅₀O₂
Molecular Weight: 442.717
Catalog: Natural product Moss
Create Date: 2018-06-26 07:59:07
Modify Date: 2024-01-02 22:28:31
Erythrodiol is an olive oil component. Erythrodiol promotes Cholesterol efflux (ChE) by selectively inhibiting the degradation of ABCA1 protein. Erythrodiol is a good candidate to be further explored for therapeutic or preventive application in the context of atherosclerosis[1].

Name	erythrodiol
Synonyms	Olean-12-ene-3,28-diol, (3β)- HOMOOLESTRANOL olean-12-ene-3,28-diol MFCD00017294 (3S,4aR,6aR,6bS,8aS,12aS,14aR,14bR)-8a-(Hydroxyméthyl)-4,4,6a,6b,11,11,14b-heptaméthyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydro-3-picénol Erythrodiol (3S,4aR,6aR,6bS,8aS,12aS,14aR,14bR)-8a-(Hydroxymethyl)-4,4,6a,6b,11,11,14b-heptamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydro-3-picenol (3β)-Olean-12-ene-3,28-diol EINECS 208-890-4 Olean-12-ene-3β,28-diol 12-OLEANENE-3,28-DIOL (3β)-Olean-12-ène-3,28-diol ERYTHODIOL Oleanolic alcohol

Description	Erythrodiol is an olive oil component. Erythrodiol promotes Cholesterol efflux (ChE) by selectively inhibiting the degradation of ABCA1 protein. Erythrodiol is a good candidate to be further explored for therapeutic or preventive application in the context of atherosclerosis[1].
Related Catalog	Research Areas >> Metabolic Disease
In Vitro	Erythrodiol (1-15 μM; 24 hours) enhances ABCA1 protein level in a concentration-dependent manner, and reachs significance at 10 and 15 μM[1]. Western Blot Analysis[1] Cell Line: THP-1 macrophage cells Concentration: 1 μM, 2.5 μM, 5 μM, 10 μM, and 15 μM Incubation Time: 24 hours Result: Increased ABCA1 protein expression.
References	[1]. Wang L, et al. Erythrodiol, an Olive Oil Constituent, Increases the Half-Life of ABCA1 and Enhances Cholesterol Efflux from THP-1-Derived Macrophages. Front Pharmacol. 2017 Jun 13;8:375.

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Risk Phrases	R22
Safety Phrases	2-45
RIDADR	NONH for all modes of transport
WGK Germany	3