Erythrodiol

Modify Date: 2024-01-02 22:28:31

Erythrodiol Structure
Erythrodiol structure
Common Name Erythrodiol
CAS Number 545-48-2 Molecular Weight 442.717
Density 1.1±0.1 g/cm3 Boiling Point 520.5±50.0 °C at 760 mmHg
Molecular Formula C30H50O2 Melting Point 230-231ºC(lit.)
MSDS Chinese USA Flash Point 209.9±24.7 °C

 Use of Erythrodiol


Erythrodiol is an olive oil component. Erythrodiol promotes Cholesterol efflux (ChE) by selectively inhibiting the degradation of ABCA1 protein. Erythrodiol is a good candidate to be further explored for therapeutic or preventive application in the context of atherosclerosis[1].

 Names

Name erythrodiol
Synonym More Synonyms

 Erythrodiol Biological Activity

Description Erythrodiol is an olive oil component. Erythrodiol promotes Cholesterol efflux (ChE) by selectively inhibiting the degradation of ABCA1 protein. Erythrodiol is a good candidate to be further explored for therapeutic or preventive application in the context of atherosclerosis[1].
Related Catalog
In Vitro Erythrodiol (1-15 μM; 24 hours) enhances ABCA1 protein level in a concentration-dependent manner, and reachs significance at 10 and 15 μM[1]. Western Blot Analysis[1] Cell Line: THP-1 macrophage cells Concentration: 1 μM, 2.5 μM, 5 μM, 10 μM, and 15 μM Incubation Time: 24 hours Result: Increased ABCA1 protein expression.
References

[1]. Wang L, et al. Erythrodiol, an Olive Oil Constituent, Increases the Half-Life of ABCA1 and Enhances Cholesterol Efflux from THP-1-Derived Macrophages. Front Pharmacol. 2017 Jun 13;8:375.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 520.5±50.0 °C at 760 mmHg
Melting Point 230-231ºC(lit.)
Molecular Formula C30H50O2
Molecular Weight 442.717
Flash Point 209.9±24.7 °C
Exact Mass 442.381073
PSA 40.46000
LogP 9.18
Vapour Pressure 0.0±3.1 mmHg at 25°C
Index of Refraction 1.551

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
Risk Phrases R22
Safety Phrases 2-45
RIDADR NONH for all modes of transport
WGK Germany 3

 Synthetic Route

 Articles22

More Articles
Potential vasorelaxant effects of oleanolic acid and erythrodiol, two triterpenoids contained in 'orujo' olive oil, on rat aorta.

Br. J. Nutr. 92(4) , 635-42, (2004)

'Orujo' olive oil is obtained by chemical processes from the waste resulting from the mechanical extraction of virgin olive oil. The aim of the present study was to evaluate a new pharmacological prop...

Changes of the wax contents in mixtures of olive oils as determined by gas chromatography with a flame ionization detector.

J. AOAC Int. 95(6) , 1720-4, (2012)

Mixing of refined olive-pomace oil with virgin olive oil is a fraud that has been tried often. Normally, the tests that detected the fraud were determinations of wax esters, erythrodiol+uvaol, and sti...

Modulation of cytokine secretion by pentacyclic triterpenes from olive pomace oil in human mononuclear cells.

Cytokine 36(5-6) , 211-7, (2006)

Olive pomace oil, also known as "orujo" olive oil, is a blend of refined-pomace oil and virgin olive oil, fit for human consumption. Maslinic acid, oleanolic acid, erythrodiol, and uvaol are pentacycl...

 Synonyms

Olean-12-ene-3,28-diol, (3β)-
HOMOOLESTRANOL
olean-12-ene-3,28-diol
MFCD00017294
(3S,4aR,6aR,6bS,8aS,12aS,14aR,14bR)-8a-(Hydroxyméthyl)-4,4,6a,6b,11,11,14b-heptaméthyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydro-3-picénol
Erythrodiol
(3S,4aR,6aR,6bS,8aS,12aS,14aR,14bR)-8a-(Hydroxymethyl)-4,4,6a,6b,11,11,14b-heptamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydro-3-picenol
(3β)-Olean-12-ene-3,28-diol
EINECS 208-890-4
Olean-12-ene-3β,28-diol
12-OLEANENE-3,28-DIOL
(3β)-Olean-12-ène-3,28-diol
ERYTHODIOL
Oleanolic alcohol
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