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22338-71-2

22338-71-2 structure
22338-71-2 structure
  • Name: Virgaureagenin G
  • Chemical Name: Polygalacic acid
  • CAS Number: 22338-71-2
  • Molecular Formula: C30H48O6
  • Molecular Weight: 504.698
  • Catalog: Biochemical Plant extracts
  • Create Date: 2018-04-12 08:00:00
  • Modify Date: 2024-01-02 17:46:30
  • Polygalacic acid, is a triterpene, isolated from the root of Polygala tenuifolia Willd. Polygalacic acid inhibits MMP expression. Polygalacic acid may have a therapeutic effect in Osteoarthritis (OA) treatment [1]. Polygalacic acid exerts a significant neuroprotective effect on cognitive impairment, PA improves cholinergic system reactivity by inhibiting acetylcholinesterase (AChE) activity, increasing choline acetyltransferase (ChAT) activity, and elevating levels of acetylcholine (Ach) in the hippocampus and frontal cortex[2].

Name Polygalacic acid
Synonyms (2b,3b,4a,16a)-2,3,16,23-Tetrahydroxyolean-12-en-28-oic acid
Polygalacic
Polygalacicacid
Virgaureagenin G
(2β,3β,5ξ,16α,18α)-2,3,16,23-Tetrahydroxyolean-12-en-28-oic acid
Vigaureagenin G
Olean-12-en-28-oic acid, 2,3,16,23-tetrahydroxy-, (2β,3β,5ξ,16α,18α)-
Polygalac Saeure
Description Polygalacic acid, is a triterpene, isolated from the root of Polygala tenuifolia Willd. Polygalacic acid inhibits MMP expression. Polygalacic acid may have a therapeutic effect in Osteoarthritis (OA) treatment [1]. Polygalacic acid exerts a significant neuroprotective effect on cognitive impairment, PA improves cholinergic system reactivity by inhibiting acetylcholinesterase (AChE) activity, increasing choline acetyltransferase (ChAT) activity, and elevating levels of acetylcholine (Ach) in the hippocampus and frontal cortex[2].
Related Catalog
In Vitro Polygalacic acid (0-100 μM; 24 hours) significantly decreases the mRNAexpressions of MMP-3, MMP-9, MMP-13, and COX-2, which are significantly increased by IL-1β, in a dose-dependent manner[1]. Polygalacic acid (0-100 μM; 6 hours) decreases the expression of phosphor-p38, phosphor-Erk, and phosphor-Jnk induced by IL-1β, phosphor-p65 is not reduced by polygalacic acid[1]. RT-PCR[1] Cell Line: Chondrocyte cells Concentration: 50 μM; 100 μM Incubation Time: 24 hours Result: Suppressed IL-1β-induced COX-2, MMP3, MMP9, and MMP13 mRNA expression. Western Blot Analysis[1] Cell Line: Chondrocyte cells Concentration: 50 μM; 100 μM Incubation Time: 6 hours Result: Inhibited the IL-1β-induced activation of the MAPK pathway in chondrocytes.
References

[1]. Xu K, et al. Polygalacic acid inhibits MMPs expression and osteoarthritis via Wnt/β-catenin and MAPK signal pathways suppression. Int Immunopharmacol. 2018 Oct;63:246-252.

[2]. Guo C, et al. Neuroprotective effects of polygalacic acid on scopolamine-induced memory deficits in mice. Phytomedicine. 2016 Feb 15;23(2):149-55.

Density 1.2±0.1 g/cm3
Boiling Point 638.1±55.0 °C at 760 mmHg
Melting Point 315-318ºC
Molecular Formula C30H48O6
Molecular Weight 504.698
Flash Point 353.7±28.0 °C
Exact Mass 504.345093
PSA 118.22000
LogP 5.03
Vapour Pressure 0.0±4.3 mmHg at 25°C
Index of Refraction 1.593
HS Code 29163990

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22338-71-2 structure

22338-71-2

Literature: Yoshikawa, Masayuki; Li, Xuezheng; Nishida, Eriko; Nakamura, Seikou; Matsuda, Hisashi; Muraoka, Osamu; Morikawa, Toshio Chemical and Pharmaceutical Bulletin, 2008 , vol. 56, # 4 p. 559 - 568

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22338-71-2 structure

22338-71-2

Literature: Yoshikawa, Masayuki; Li, Xuezheng; Nishida, Eriko; Nakamura, Seikou; Matsuda, Hisashi; Muraoka, Osamu; Morikawa, Toshio Chemical and Pharmaceutical Bulletin, 2008 , vol. 56, # 4 p. 559 - 568

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Detail
Literature: Hernandez-Carlos, Beatriz; Carmona-Pineda, Miriam; Villanueva-Canongo, Claudia; Lopez-Olguin, Jesus F.; Aragon-Garcia, Agustin; Joseph-Nathan, Pedro Magnetic Resonance in Chemistry, 2009 , vol. 47, # 11 p. 994 - 1003

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Detail
Literature: Hernandez-Carlos, Beatriz; Carmona-Pineda, Miriam; Villanueva-Canongo, Claudia; Lopez-Olguin, Jesus F.; Aragon-Garcia, Agustin; Joseph-Nathan, Pedro Magnetic Resonance in Chemistry, 2009 , vol. 47, # 11 p. 994 - 1003
Precursor  1

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