- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: Virgaureagenin G
- Price:
- Purity: 98.0%
- Stocking Period: 10 Day
- Contact: Yang
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Virgaureagenin G
- Price: ￥2418.0/20mg ￥1078.0/20mg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Liu jia
- DC Chemicals Limited
- China
- Product Name: Polygalacic acid
- Price: $280.0/20mg
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: Polygalacic acid
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
22338-71-2
22338-71-2 structure
- Name: Virgaureagenin G
- Chemical Name: Polygalacic acid
- CAS Number: 22338-71-2
- Molecular Formula: C30H48O6
- Molecular Weight: 504.698
- Catalog: Biochemical Plant extracts
- Create Date: 2018-04-12 08:00:00
- Modify Date: 2024-01-02 17:46:30
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Polygalacic acid, is a triterpene, isolated from the root of Polygala tenuifolia Willd. Polygalacic acid inhibits MMP expression. Polygalacic acid may have a therapeutic effect in Osteoarthritis (OA) treatment [1]. Polygalacic acid exerts a significant neuroprotective effect on cognitive impairment, PA improves cholinergic system reactivity by inhibiting acetylcholinesterase (AChE) activity, increasing choline acetyltransferase (ChAT) activity, and elevating levels of acetylcholine (Ach) in the hippocampus and frontal cortex[2].
| Name | Polygalacic acid |
|---|---|
| Synonyms |
(2b,3b,4a,16a)-2,3,16,23-Tetrahydroxyolean-12-en-28-oic acid
Polygalacic Polygalacicacid Virgaureagenin G (2β,3β,5ξ,16α,18α)-2,3,16,23-Tetrahydroxyolean-12-en-28-oic acid Vigaureagenin G Olean-12-en-28-oic acid, 2,3,16,23-tetrahydroxy-, (2β,3β,5ξ,16α,18α)- Polygalac Saeure |
| Description | Polygalacic acid, is a triterpene, isolated from the root of Polygala tenuifolia Willd. Polygalacic acid inhibits MMP expression. Polygalacic acid may have a therapeutic effect in Osteoarthritis (OA) treatment [1]. Polygalacic acid exerts a significant neuroprotective effect on cognitive impairment, PA improves cholinergic system reactivity by inhibiting acetylcholinesterase (AChE) activity, increasing choline acetyltransferase (ChAT) activity, and elevating levels of acetylcholine (Ach) in the hippocampus and frontal cortex[2]. |
|---|---|
| Related Catalog | |
| In Vitro | Polygalacic acid (0-100 μM; 24 hours) significantly decreases the mRNAexpressions of MMP-3, MMP-9, MMP-13, and COX-2, which are significantly increased by IL-1β, in a dose-dependent manner[1]. Polygalacic acid (0-100 μM; 6 hours) decreases the expression of phosphor-p38, phosphor-Erk, and phosphor-Jnk induced by IL-1β, phosphor-p65 is not reduced by polygalacic acid[1]. RT-PCR[1] Cell Line: Chondrocyte cells Concentration: 50 μM; 100 μM Incubation Time: 24 hours Result: Suppressed IL-1β-induced COX-2, MMP3, MMP9, and MMP13 mRNA expression. Western Blot Analysis[1] Cell Line: Chondrocyte cells Concentration: 50 μM; 100 μM Incubation Time: 6 hours Result: Inhibited the IL-1β-induced activation of the MAPK pathway in chondrocytes. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 638.1±55.0 °C at 760 mmHg |
| Melting Point | 315-318ºC |
| Molecular Formula | C30H48O6 |
| Molecular Weight | 504.698 |
| Flash Point | 353.7±28.0 °C |
| Exact Mass | 504.345093 |
| PSA | 118.22000 |
| LogP | 5.03 |
| Vapour Pressure | 0.0±4.3 mmHg at 25°C |
| Index of Refraction | 1.593 |
| HS Code | 29163990 |
|---|
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22338-71-2 |
| Literature: Yoshikawa, Masayuki; Li, Xuezheng; Nishida, Eriko; Nakamura, Seikou; Matsuda, Hisashi; Muraoka, Osamu; Morikawa, Toshio Chemical and Pharmaceutical Bulletin, 2008 , vol. 56, # 4 p. 559 - 568 |
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22338-71-2 |
| Literature: Yoshikawa, Masayuki; Li, Xuezheng; Nishida, Eriko; Nakamura, Seikou; Matsuda, Hisashi; Muraoka, Osamu; Morikawa, Toshio Chemical and Pharmaceutical Bulletin, 2008 , vol. 56, # 4 p. 559 - 568 |
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| Literature: Hernandez-Carlos, Beatriz; Carmona-Pineda, Miriam; Villanueva-Canongo, Claudia; Lopez-Olguin, Jesus F.; Aragon-Garcia, Agustin; Joseph-Nathan, Pedro Magnetic Resonance in Chemistry, 2009 , vol. 47, # 11 p. 994 - 1003 |
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Detail
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| Literature: Hernandez-Carlos, Beatriz; Carmona-Pineda, Miriam; Villanueva-Canongo, Claudia; Lopez-Olguin, Jesus F.; Aragon-Garcia, Agustin; Joseph-Nathan, Pedro Magnetic Resonance in Chemistry, 2009 , vol. 47, # 11 p. 994 - 1003 |
| Precursor 1 | |
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| DownStream 0 | |