106391-85-9

106391-85-9 structure

Name: D-Boc valine methyl ester
Chemical Name: D-Boc valine methyl ester
CAS Number: 106391-85-9
Molecular Formula: C₁₁H₂₁NO₄
Molecular Weight: 231.28900
Catalog: Research Areas Cancer
Create Date: 2017-09-30 05:15:08
Modify Date: 2024-01-29 13:47:39
D-Boc Valine methyl ester is an intermediate in the synthesis of Taltobulin (HY-15584). Taltobulin is a common toxin component in ADC preparation (ADC Cytotoxin), and it is also a powerful tubulin (Microtubule/Tubulin) inhibitor. Taltobulin disrupts tubulin polymerization, induces mitotic arrest, and induces apoptosis[1].

Name	D-Boc valine methyl ester
Synonyms	N-tert-Butoxycarbonyl-D-valine methyl ester Methyl N-{[(2-Methyl-2-Propanyl)Oxy]Carbonyl}-D-Valinate Boc-D-Val-OMe

Description	D-Boc Valine methyl ester is an intermediate in the synthesis of Taltobulin (HY-15584). Taltobulin is a common toxin component in ADC preparation (ADC Cytotoxin), and it is also a powerful tubulin (Microtubule/Tubulin) inhibitor. Taltobulin disrupts tubulin polymerization, induces mitotic arrest, and induces apoptosis[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. Loganzo F, et al. HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Cancer Res. 2003 Apr 15;63(8):1838-45.

HS Code	2924199090

Precursor 0
DownStream 4
86695-06-9 7146-15-8 191090-32-1 223906-38-5

HS Code	2924199090
Summary	2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%