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145781-92-6

145781-92-6 structure
145781-92-6 structure
  • Name: (D-Ser(tBu)6,AzaGly10)-LHRH acetate salt
  • Chemical Name: Goserelin Acetate
  • CAS Number: 145781-92-6
  • Molecular Formula: C61H88N18O16
  • Molecular Weight: 1329.46
  • Catalog: API Hormone and endocrine-regulating drugs Gonadotropin
  • Create Date: 2018-02-07 08:00:00
  • Modify Date: 2024-01-02 02:35:58
  • Goserelin (ICI 118630) acetate is an injectable gonadotropin releasing hormone superagonist (GnRH agonist).IC50 value:Target: GnRH agonistGoserelin is used to treat hormone-sensitive cancers of the breast (in pre- and peri- menopausal women) and prostate, and some benign gynaecological disorders (endometriosis, uterine fibroids and endometrial thinning). In addition, goserelin is used in assisted reproduction and in the treatment of precocious puberty. It may also be used in the treatment of male-to-female transsexuals and is favoured above other anti-androgens in some countries, such as the UK. It is available as a 1-month depot and a long-acting 3-month depot. Goserelin stimulates the production of the sex hormones testosterone and estrogen in a non-pulsatile (non-physiological) manner.

Name Goserelin Acetate
Synonyms Goserelin acetate
Goserelin acetate [D-Ser(tBu)6,Azagly10]-LHRH acetate salt
Goserelin (acetate)
Description Goserelin (ICI 118630) acetate is an injectable gonadotropin releasing hormone superagonist (GnRH agonist).IC50 value:Target: GnRH agonistGoserelin is used to treat hormone-sensitive cancers of the breast (in pre- and peri- menopausal women) and prostate, and some benign gynaecological disorders (endometriosis, uterine fibroids and endometrial thinning). In addition, goserelin is used in assisted reproduction and in the treatment of precocious puberty. It may also be used in the treatment of male-to-female transsexuals and is favoured above other anti-androgens in some countries, such as the UK. It is available as a 1-month depot and a long-acting 3-month depot. Goserelin stimulates the production of the sex hormones testosterone and estrogen in a non-pulsatile (non-physiological) manner.
Related Catalog
Density 1.5±0.1 g/cm3
Boiling Point 1695.5ºC at 760mmHg
Melting Point >190°C (dec.)
Molecular Formula C61H88N18O16
Molecular Weight 1329.46
PSA 493.39000
LogP -0.95
Vapour Pressure 0mmHg at 25°C
Index of Refraction 1.692
Storage condition −20°C
Water Solubility H2O: 20 mg/mL, clear, colorless
Symbol GHS08
GHS08
Signal Word Danger
Hazard Statements H360
Precautionary Statements P201-P280-P308 + P313
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases 22-24/25
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS OK6369800