36505-84-7
36505-84-7 structure
- Name: Buspirone
- Chemical Name: buspirone
- CAS Number: 36505-84-7
- Molecular Formula: C21H31N5O2
- Molecular Weight: 385.50300
- Catalog: API Nervous system medication Anxiolytic
- Create Date: 2018-03-24 08:00:00
- Modify Date: 2024-01-02 13:43:33
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Buspirone is an orally active 5-HT1A receptor agonist. Buspirone is a potent anticancer agent. Buspirone shows antiproliferative activity. Buspirone can be used for anxiety, depression and cancer research[1][2].
| Name | buspirone |
|---|---|
| Synonyms |
Ansial
8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro(4.5)-decane-7,9-dione EINECS 253-072-2 Anxiron 8-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-8-azaspiro[4.5]decane-7,9-dione MFCD00078569 Buspironum [INN-Latin] Buspironum Ansiced Bespar Buspirona [INN-Spanish] [14C]-Buspirone 8-[4-[4-(pyrimidine-2-yl)-piperazine-1-yl]-butyl]-8-aza-spiro[4.5]decane-7,9-dione Buspirona |
| Description | Buspirone is an orally active 5-HT1A receptor agonist. Buspirone is a potent anticancer agent. Buspirone shows antiproliferative activity. Buspirone can be used for anxiety, depression and cancer research[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | Buspirone (0-400 µg/mL; 6 hours) has cytotoxic effect in Lymphocytes[1].Buspirone (0-180 µg/mL; 0-3 hours; Lymphocytes)induces ROS formation, mitochondrial membrane potential collapse(MMP), lipid peroxidation, lysosomal damage and elevation of glutathione disulfide (GSSG)[1]. Cell Viability Assay[1] Cell Line: Lymphocytes Concentration: 0, 4, 20, 40, 200 and 400 µg/mL Incubation Time: 6 hours Result: Decreased cell viability in a dose-dependent manner. |
| In Vivo | Buspirone (1-5 mg/kg; i.p. and i.g.; for 5 days; C57BL/6N mice) reduces anxiety/depression behaviors[2]. Buspirone (1-5 mg/kg; i.p. and i.g.; for 5 days; C57BL/6N mice) restores IS-shifted β-diversity in the gut microbiota[2]. Animal Model: Male C57BL/6N mice[2] Dosage: 1 and 5 mg/kg Administration: Oral gavage and intraperitoneal injection; for 5 days Result: Reduced TNF-α expression and NF-κB+/Iba1+ cell population in the hippocampus and myeloperoxidase activity and NF-κB+/CD11c+ cell population in the colon. Animal Model: Male C57BL/6N mice[2] Dosage: 1 and 5 mg/kg Administration: Oral gavage and intraperitoneal injection; for 5 days Result: Reduced the IS- or EC-induced gut Proteobacteria population. |
| References |
| Density | 1.24g/cm3 |
|---|---|
| Boiling Point | 613.9ºC at 760 mmHg |
| Melting Point | 41678ºC |
| Molecular Formula | C21H31N5O2 |
| Molecular Weight | 385.50300 |
| Flash Point | 325.1ºC |
| Exact Mass | 385.24800 |
| PSA | 69.64000 |
| LogP | 2.02900 |
| Storage condition | 2-8°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
| Hazard Codes | T: Toxic; |
|---|---|
| Risk Phrases | R25 |
| Safety Phrases | S45 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | CL9915000 |
| HS Code | 2933990090 |
| Precursor 10 | |
|---|---|
| DownStream 1 | |
![8-(2-Pyrimidinyl)-8-aza-5-azoniaspiro[4.5]decane Bromide structure](https://image.chemsrc.com/caspic/372/81461-73-6.png)
![8-(4-Bromobutyl)-8-azaspiro[4.5]decane-7,9-dione structure](https://image.chemsrc.com/caspic/016/80827-62-9.png)
![8-[4-(4-pyrimidin-2-yl-piperazin-1-yl)but-2-enyl]-8-aza-spiro[4.5]decane-7,9-dione structure](https://image.chemsrc.com/caspic/220/118286-98-9.png)
![8-[4-[4-(2-Pyrimidinyl)-1-piperazinyl]-2-butynyl]-8-azaspiro[4.5]decane-7,9-dione structure](https://image.chemsrc.com/caspic/258/118286-97-8.png)
![8-(prop-2-ynyl)-8-azaspiro[4.5]decane-7,9-dione structure](https://image.chemsrc.com/caspic/254/25032-23-9.png)
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |