102783-53-9

102783-53-9 structure

Name: 2,3-DIPHOSPHO-D-GLYCERIC ACID PENTASODIUM SALT
Chemical Name: 2,3-Diphospho-D-glyceric acid pentasodium salt
CAS Number: 102783-53-9
Molecular Formula: C₃H₃Na₅O₁₀P₂
Molecular Weight: 375.946
Catalog: Research Areas Cardiovascular Disease
Create Date: 2018-12-10 20:40:23
Modify Date: 2024-01-03 20:32:42
2,3-Diphospho-D-glyceric acid pentasodium salt is a highly anionic polyphosphorus compound. 2,3-Diphospho-D-glyceric acid is present in the concave center of red blood cells, it binds hemoglobin to reduce its oxygen affinity. 2,3-Diphospho-D-glyceric acid is an endogenous, selective inhibitor of vascular calcification (VC) and significantly delays the formation of crystalline calpain particles (CPP). 2,3-Diphospho-D-glyceric acid also inhibits calcification in mouse vascular smooth muscle cell line (MOVAS) without cytotoxic effects[1].

Name	2,3-Diphospho-D-glyceric acid pentasodium salt
Synonyms	Pentasodium (2R)-2,3-bis(phosphonatooxy)propanoate Propanoic acid, 2,3-bis(phosphonooxy)-, sodium salt, (2R)- (1:5) 2,3-diphospho-d-glyceric acid pentasodium salt

Description	2,3-Diphospho-D-glyceric acid pentasodium salt is a highly anionic polyphosphorus compound. 2,3-Diphospho-D-glyceric acid is present in the concave center of red blood cells, it binds hemoglobin to reduce its oxygen affinity. 2,3-Diphospho-D-glyceric acid is an endogenous, selective inhibitor of vascular calcification (VC) and significantly delays the formation of crystalline calpain particles (CPP). 2,3-Diphospho-D-glyceric acid also inhibits calcification in mouse vascular smooth muscle cell line (MOVAS) without cytotoxic effects[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others
References	[1]. Kharaghani D, Kohno S, Minamizaki T, et al. 2, 3-Diphospho-D-glyceric acid inhibits calciprotein particle growth and calcification in MOVAS cells but not in MC3T3-E1 cells[J]. Colloid and Interface Science Communications, 2022, 50: 100668.

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