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83928-76-1

83928-76-1 structure
83928-76-1 structure
  • Name: gepirone
  • Chemical Name: 4,4-Dimethyl-1-(4-(4-(pyrimidin-2-yl)piperazin-1-yl)butyl)piperidine-2,6-dione
  • CAS Number: 83928-76-1
  • Molecular Formula: C19H29N5O2
  • Molecular Weight: 359.47
  • Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
  • Create Date: 2018-08-09 19:04:32
  • Modify Date: 2024-01-04 11:22:38
  • Gepirone is a selectively and affinitive 5-HT1A agonist. Gepirone binds selectively to 5-HT1A receptor binding site. Gepirone acts as an antidepressant agent can be used for anxiety and major depressive disorder research[1].
Name 4,4-Dimethyl-1-(4-(4-(pyrimidin-2-yl)piperazin-1-yl)butyl)piperidine-2,6-dione
Synonyms 3,3-Dimethyl-1-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]glutarimide
gepirone
4,4-Dimethyl-1-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-2,6-piperidinedione
4,4-Dimethyl-1-{4-[4-(pyrimidin-2-yl)piperazin-1-yl]butyl}piperidine-2,6-dione
2,6-Piperidinedione, 4,4-dimethyl-1-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-
4,4-Dimethyl-1-{4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl}-2,6-piperidinedione
4,4-dimethyl-1-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]piperidine-2,6-dione
Description Gepirone is a selectively and affinitive 5-HT1A agonist. Gepirone binds selectively to 5-HT1A receptor binding site. Gepirone acts as an antidepressant agent can be used for anxiety and major depressive disorder research[1].
Related Catalog
Target

5-HT1A Receptor

References

[1]. Mendelson SD, et al. Effects of 5-HT1A selective anxiolytics on lordosis behavior: interactions with progesterone. Eur J Pharmacol. 1986 Dec 16;132(2-3):323-6.  

[2]. Blier P, et al. Modification of 5-HT neuron properties by sustained administration of the 5-HT1A agonist gepirone: electrophysiological studies in the rat brain. Synapse. 1987;1(5):470-80.  

Density 1.1±0.1 g/cm3
Boiling Point 562.3±60.0 °C at 760 mmHg
Molecular Formula C19H29N5O2
Molecular Weight 359.47
Flash Point 293.8±32.9 °C
Exact Mass 359.232117
PSA 69.64000
LogP 2.95
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.542
HS Code 2933990090
124475-86-1 structure

124475-86-1

~69%

83928-76-1 structure

83928-76-1

Literature: Kuo, David L. Heterocycles, 1993 , vol. 36, # 7 p. 1463 - 1470
20980-22-7 structure

20980-22-7

84951-42-8 structure

84951-42-8

~%

83928-76-1 structure

83928-76-1

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 7 p. 1709 - 1712
1123-40-6 structure

1123-40-6

~%

83928-76-1 structure

83928-76-1

Literature: Heterocycles, , vol. 36, # 7 p. 1463 - 1470
1123-40-6 structure

1123-40-6

81461-73-6 structure

81461-73-6

~%

83928-76-1 structure

83928-76-1

Literature: Archiv der Pharmazie, , vol. 325, # 5 p. 313 - 315
110-52-1 structure

110-52-1

1123-40-6 structure

1123-40-6

20980-22-7 structure

20980-22-7

~%

83928-76-1 structure

83928-76-1

Literature: Archiv der Pharmazie, , vol. 325, # 5 p. 313 - 315
HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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title: CAS No. 83928-76-1 | Chemsrc address: https://www.chemsrc.com/en/baike/833821.html

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