159776-69-9

159776-69-9 structure

Name: Cemadotin
Chemical Name: (2S)-1-benzyl-N-[(2S)-2-[[(2S)-2-(dimethylamino)-3-methylbutanoyl]amino]-3-methylbutanoyl]-N-[(2S)-1-[(2S)-3-methyl-2-(methylamino)butanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carboxamide
CAS Number: 159776-69-9
Molecular Formula: C₃₅H₅₆N₆O₅
Molecular Weight: 640.85600
Catalog: Signaling Pathways Cell Cycle/DNA Damage Microtubule/Tubulin
Create Date: 2018-04-15 08:00:00
Modify Date: 2024-01-08 14:13:20
Cemadotin (LU103793) is an analogue of Dolastatin 15 (HY-P1126) which is naturally occurring cytotoxic peptides. Cemadotin blocks cells at mitosis, and exhibits Ki value of 1 μM for inhibiting tubulin. Cemadotin can be used to research anticancer[1].

Name	(2S)-1-benzyl-N-[(2S)-2-[[(2S)-2-(dimethylamino)-3-methylbutanoyl]amino]-3-methylbutanoyl]-N-[(2S)-1-[(2S)-3-methyl-2-(methylamino)butanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carboxamide
Synonyms	UNII-6SQ8M7ZSFV N,N-Dimethyl-L-valyl-L-valyl-N-methyl-L-valyl-L-prolyl-N-benzyl-L-prolinamide Cemadotin N,N-dimethyl-L-valyl-L-valyl-N-methyl-L-valyl-L-prolyl-N-(phenylmethyl)-L-prolinamide L-Prolinamide,N,N-dimethyl-L-valyl-L-valyl-N-methyl-L-valyl-L-prolyl-N-(phenylmethyl)

Description	Cemadotin (LU103793) is an analogue of Dolastatin 15 (HY-P1126) which is naturally occurring cytotoxic peptides. Cemadotin blocks cells at mitosis, and exhibits Ki value of 1 μM for inhibiting tubulin. Cemadotin can be used to research anticancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin
Target	Ki: 1 μM (tubulin)[1]
In Vitro	Cemadotin (0-100 μM; 35 min) inhibits polymerization dose-dependently in Tubulin-treated Strongylocentrotus purpuratus[1]. Cemadotin (0-1000 nM) preferentially suppresses the rate and extent of growing excursions of tubulin, and suppression is dependent upon the drug concentration[1]. Cemadotin (0-1 μM) markedly increases the rescue frequency but had little effect on the catastrophe frequency[1]. Cemadotin (400 pM~300 nM; 72 h) inhibits cancer cells HEK 293, F9 and HL60[2]. Cell Proliferation Assay[2] Cell Line: HEK 293, F9 and HL60 Concentration: 400 pM~300 nM Incubation Time: 72 h Result: Exhibited cytotoxicity against HEK 293, F9 and HL60 with IC50s of 0.7 nM, 14.8 nM and 0.5 nM, respectively.