81065-76-1
81065-76-1 structure
- Name: EUK-134
- Chemical Name: manganese(2+),2-methoxy-6-[2-[(3-methoxy-2-oxidophenyl)methylideneamino]ethyliminomethyl]phenolate,chloride
- CAS Number: 81065-76-1
- Molecular Formula: C18H18ClMnN2O4
- Molecular Weight: 416.738
- Catalog: Biochemical Inhibitor Neuronal Signaling Beta Amyloid inhibitor
- Create Date: 2018-10-20 04:52:55
- Modify Date: 2024-01-02 13:47:50
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EUK-134, a synthetic superoxide dismutase and catalase mimetic, protects rat kidneys from ischemia-reperfusion-induced damage. EUK-134 is a superoxide dismutase (SOD) mimetics (SODm) with catalase activity. EUK-134 is a mitoprotective antioxidant. EUK-134 reduces the expression of NF-κB, MDA level, and protein carbonylation in H9C2 cells[1][2][3].
| Name | manganese(2+),2-methoxy-6-[2-[(3-methoxy-2-oxidophenyl)methylideneamino]ethyliminomethyl]phenolate,chloride |
|---|---|
| Synonyms |
Phenol, 2,2'-[1,2-ethanediylbis[nitrilo(E)methylidyne]]bis[6-methoxy-, manganese(3+) salt, hydrochloride (1:1:1)
ethylbisiminomethylguaiacol manganese chloride Manganese(3+) chloride 2,2'-{1,2-ethanediylbis[nitrilo(E)methylylidene]}bis(6-methoxyphenolate) (1:1:1) I14-7464 EUK-134 |
| Description | EUK-134, a synthetic superoxide dismutase and catalase mimetic, protects rat kidneys from ischemia-reperfusion-induced damage. EUK-134 is a superoxide dismutase (SOD) mimetics (SODm) with catalase activity. EUK-134 is a mitoprotective antioxidant. EUK-134 reduces the expression of NF-κB, MDA level, and protein carbonylation in H9C2 cells[1][2][3]. |
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| Related Catalog | |
| Target |
NF-κB |
| In Vitro | EUK-134 (10-300 μM) is able to improve cell viability and reduces Paraquat (1 mM)-induced cell death significantly via dismutation or scavenging of superoxide anions and reduces hydroxyl radical generation[2]. Higher concentrations of EUK-134 alone (30-300 μM) produces modest but significant reductions in cellular viability; however, this effect is not reflected in cell death measurements made at these concentrations[2]. EUK-134 is a salen-manganese complex with superoxide dismutase and catalase activity.Supplementation with EUK-134 is therefore identified as a novel approach to attenuate cardiac hypertrophy and lends scope for the development of EUK-134 as a therapeutic agent in the management of human cardiovascular disease.EUK-134 is a mitoprotective antioxidant with Mn-superoxide dismutase (Mn SOD) and catalase activity[3]. Cell Viability Assay[2] Cell Line: NRK-52E cells Concentration: 0, 1, 3, 10, 30, 100, and 300 μM Incubation Time: 24 hours Result: Co-incubation with Paraquat (1 mM) and increasing concentrations of EUK-134 (1-300 μM) resulted in a significant reduction in paraquat-induced cellular injury and death at 100 and 300 μM. |
| References |
| Molecular Formula | C18H18ClMnN2O4 |
|---|---|
| Molecular Weight | 416.738 |
| Exact Mass | 416.033569 |
| PSA | 58.62000 |
| LogP | 3.09010 |
| Appearance | , faint to very dark brown |
| Storage condition | ?20°C |
| Water Solubility | H2O: soluble2mg/mL, clear (warmed) |
| RIDADR | NONH for all modes of transport |
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