688348-33-6

688348-33-6 structure

Name: CAY 10465
Chemical Name: 1,3-dichloro-5-[2-[4-(trifluoromethyl)phenyl]ethenyl]benzene
CAS Number: 688348-33-6
Molecular Formula: C₁₅H₉Cl₂F₃
Molecular Weight: 317.133
Catalog: Signaling Pathways Immunology/Inflammation Aryl Hydrocarbon Receptor
Create Date: 2016-07-08 03:41:52
Modify Date: 2024-01-04 19:31:03
CAY 10465 is a selective and high-affinity AhR agonist, with a Ki of 0.2 nM, and shows no effect on estrogen receptor (Ki >100000 nM).

Name	1,3-dichloro-5-[2-[4-(trifluoromethyl)phenyl]ethenyl]benzene
Synonyms	1,3-Dichloro-5-{(E)-2-[4-(trifluoromethyl)phenyl]vinyl}benzene 1,3-dichloro-5-{(E)-2-[4-(trifluoromethyl)phenyl]ethenyl}benzene Benzene, 1,3-dichloro-5-[(E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-

Description	CAY 10465 is a selective and high-affinity AhR agonist, with a Ki of 0.2 nM, and shows no effect on estrogen receptor (Ki >100000 nM).
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Aryl Hydrocarbon Receptor Research Areas >> Cardiovascular Disease
Target	Ki: 0.2 nM (AhR)[1]
In Vitro	CAY 10465 (Compound 4i) is a selective and high-affinity AhR receptor agonist, with a Ki of 0.2 nM, and shows no effect on estrogen receptor (Ki >100000 nM)[1]. CAY 10465 (0.01 nM-100 μM) reduces apolipoprotein A-I (apo A-I) levels in HepG2 cells, and inhibits the synthesis of the protein[2].
References	[1]. de Medina P, et al. Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators. J Med Chem. 2005 Jan 13;48(1):287-91. [2]. Naem E, et al. Inhibition of apolipoprotein A-I gene by the aryl hydrocarbon receptor: a potential mechanism for smoking-associated hypoalphalipoproteinemia. Life Sci. 2012 Jul 26;91(1-2):64-9.