359714-55-9

359714-55-9 structure

Name: CAY10499
Chemical Name: cay10499
CAS Number: 359714-55-9
Molecular Formula: C₁₈H₁₇N₃O₅
Molecular Weight: 355.345
Catalog: Signaling Pathways Metabolic Enzyme/Protease FAAH
Create Date: 2016-05-25 23:10:33
Modify Date: 2024-01-03 14:13:39
MAGL-IN-5 is a non-selective lipase inhibitor with IC50 values of 144, 90, and 14 nM for human recombinant monoacylglycerol lipase(MAGL),hormone sensitive lipase(HSL), and fatty acid amide hydrolase(FAAH) respectively[1][2].

Name	cay10499
Synonyms	Carbamic acid, N-[4-(5-methoxy-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-2-methylphenyl]-, phenylmethyl ester Benzyl [4-(5-methoxy-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-2-methylphenyl]carbamate

Description	MAGL-IN-5 is a non-selective lipase inhibitor with IC50 values of 144, 90, and 14 nM for human recombinant monoacylglycerol lipase(MAGL),hormone sensitive lipase(HSL), and fatty acid amide hydrolase(FAAH) respectively[1][2].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> MAGL Signaling Pathways >> Metabolic Enzyme/Protease >> FAAH Research Areas >> Metabolic Disease Signaling Pathways >> Neuronal Signaling >> FAAH
References	[1]. Muccioli GG, et al. CAY10499, a novel monoglyceride lipase inhibitor evidenced by an expeditious MGL assay. Chembiochem. 2008 Nov 3;9(16):2704-10. [2]. Granchi C, et al. 4-Aryliden-2-methyloxazol-5(4H)-one as a new scaffold for selective reversible MAGL inhibitors. J Enzyme Inhib Med Chem. 2016;31(1):137-46.