849067-18-1

849067-18-1 structure

Name: 2-(Acetylsulfamoyl)benzoic acid
Chemical Name: N-acetyl-2-carboxy Benzenesulfonamide
CAS Number: 849067-18-1
Molecular Formula: C₉H₉NO₅S
Molecular Weight: 243.24
Catalog: Signaling Pathways Immunology/Inflammation COX
Create Date: 2017-10-06 15:31:23
Modify Date: 2024-01-12 00:36:43
N-Acetyl-2-carboxybenzenesulfonamide is an orally active COX-1 and COX-2 inhibitor with IC50s of 0.06 μM and 0.25 μM, respectively. N-Acetyl-2-carboxybenzenesulfonamide shows anti-inflammatory activity[1].

Name	N-acetyl-2-carboxy Benzenesulfonamide
Synonyms	2-(Acetylsulfamoyl)benzoic acid Benzoic acid, 2-[(acetylamino)sulfonyl]-

Description	N-Acetyl-2-carboxybenzenesulfonamide is an orally active COX-1 and COX-2 inhibitor with IC50s of 0.06 μM and 0.25 μM, respectively. N-Acetyl-2-carboxybenzenesulfonamide shows anti-inflammatory activity[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX
Target	IC50: 0.06 μM (COX-1), 0.25 μM (COX-2)[1]
References	[1]. ChenQH, et al. Design, synthesis, and biological evaluation ofN-acetyl-2-carboxybenzenesulfonamides: a novel class of cyclooxygenase-2(COX-2) inhibitors. Bioorg Med Chem. 2005 Apr 1;13(7):2459-68. [2]. Chen QH, et al. Design, synthesis, and biological evaluation of N-acetyl-2-carboxybenzenesulfonamides: a novel class of cyclooxygenase-2 (COX-2) inhibitors. Bioorg Med Chem. 2005 Apr 1;13(7):2459-68.