CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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XP3582990
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CHEMICAL NAME :
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Thyroxine, monosodium salt, D-
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CAS REGISTRY NUMBER :
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137-53-1
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LAST UPDATED :
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199709
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DATA ITEMS CITED :
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7
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MOLECULAR FORMULA :
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C15-H10-I4-N-O4.Na
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MOLECULAR WEIGHT :
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798.85
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WISWESSER LINE NOTATION :
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QR BI FI DOR BI FI D1YZVO &-NA-
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Human - woman
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DOSE/DURATION :
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12 ug/kg/12D-I
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TOXIC EFFECTS :
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Liver - hepatitis (hepatocellular necrosis), diffuse Liver - liver function tests impaired Nutritional and Gross Metabolic - body temperature increase
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REFERENCE :
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JJMDAT Japanese Journal of Medicine. (Nankodo Co., Ltd., POB 5272, Tokyo International 100-31, Japan) V.1-30, 1962-1991. For publisher information, see IEDIEP. Volume(issue)/page/year: 23,282,1984 ** OTHER MULTIPLE DOSE TOXICITY DATA **
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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1500 mg/kg/30D-C
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TOXIC EFFECTS :
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Vascular - BP elevation not characterized in autonomic section Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
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REFERENCE :
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TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. (Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532, Japan) V.29- 1970- Volume(issue)/page/year: 29,207,1970
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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222 mg/kg/24W-C
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TOXIC EFFECTS :
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Vascular - BP elevation not characterized in autonomic section Kidney, Ureter, Bladder - changes in bladder weight Endocrine - evidence of thyroid hyperfunction
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REFERENCE :
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TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. (Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532, Japan) V.29- 1970- Volume(issue)/page/year: 29,565,1970 ** REPRODUCTIVE DATA **
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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29 mg/kg
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SEX/DURATION :
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female 1-29 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Effects on Embryo or Fetus - fetal death
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REFERENCE :
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DABBBA Dissertation Abstracts International, B: The Sciences and Engineering. (University Microfilms International, 300 N. Zeeb Rd., Ann Arbor, MI 48106) V.30- 1969- Volume(issue)/page/year: 32,1182,1971
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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15 mg/kg
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SEX/DURATION :
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female 15-29 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Effects on Newborn - physical
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REFERENCE :
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DABBBA Dissertation Abstracts International, B: The Sciences and Engineering. (University Microfilms International, 300 N. Zeeb Rd., Ann Arbor, MI 48106) V.30- 1969- Volume(issue)/page/year: 32,1182,1971
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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16 mg/kg
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SEX/DURATION :
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female 16-31 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system
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REFERENCE :
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SDMEAL South Dakota Journal of Medicine. (South Dakota Medical Assoc., 608 West Ave. N, Sioux Falls, SD 57104) V.18- 1965- Volume(issue)/page/year: 21,33,1968 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5407 No. of Facilities: 9 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 63 (estimated) No. of Female Employees: 9 (estimated)
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