661464-94-4

661464-94-4 structure

Name: Levalbuterol tartrate
Chemical Name: 4-[(1R)-2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol,(2R,3R)-2,3-dihydroxybutanedioic acid
CAS Number: 661464-94-4
Molecular Formula: C₃₀H₄₈N₂O₁₂
Molecular Weight: 628.71
Catalog: Signaling Pathways GPCR/G Protein Adrenergic Receptor
Create Date: 2018-09-15 09:37:28
Modify Date: 2024-01-08 12:35:11
Levosalbutamol tartrate(levalbuterol) is the R-enantiomer of the short-acting β2-adrenergic receptor agonist salbutamol. IC50 Value:Target: β2-adrenergic receptorLevosalbutamol and salbutamol produced significantly better bronchodilator responses than placebo. Both the drugs showed equivalent time-dependent bronchodilator responses as measured by area under curve for percent change in FEV(1) and FVC over 6h. The time to onset of action, mean maximum bronchodilator response and duration of bronchodilator response were similar between levosalbutamol and salbutamol [1].

Name	4-[(1R)-2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol,(2R,3R)-2,3-dihydroxybutanedioic acid
Synonyms	Levalbuterol tartrate Xopenex HFA (2R,3R)-2,3-Dihydroxysuccinic acid - 2-(hydroxymethyl)-4-{(1R)-1-hydroxy-2-[(2-methyl-2-propanyl)amino]ethyl}phenol (1:2) Butanedioic acid, 2,3-dihydroxy-, (2R,3R)-, compd. with (αR)-α-[[(1,1-dimethylethyl)amino]methyl]-4-hydroxy-1,3-benzenedimethanol (1:2)

Description	Levosalbutamol tartrate(levalbuterol) is the R-enantiomer of the short-acting β2-adrenergic receptor agonist salbutamol. IC50 Value:Target: β2-adrenergic receptorLevosalbutamol and salbutamol produced significantly better bronchodilator responses than placebo. Both the drugs showed equivalent time-dependent bronchodilator responses as measured by area under curve for percent change in FEV(1) and FVC over 6h. The time to onset of action, mean maximum bronchodilator response and duration of bronchodilator response were similar between levosalbutamol and salbutamol [1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Neurological Disease
References	[1]. Jantikar A, et al. Comparison of bronchodilator responses of levosalbutamol and salbutamol given via a pressurized metered dose inhaler: a randomized, double blind, single-dose, crossover study. Respir Med. 2007 Apr;101(4):845-9.