18877-64-0

18877-64-0 structure

Name: L-Palmitoylcarnitine chloride
Chemical Name: palmitoyl-l-carnitine chloride
CAS Number: 18877-64-0
Molecular Formula: C₂₃H₄₆ClNO₄
Molecular Weight: 436.069
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Potassium Channel
Create Date: 2018-07-25 05:06:37
Modify Date: 2024-01-05 23:36:37
L-Palmitoylcarnitine chloride, a long-chain acylcarnitine and a fatty acid metabolite, accumulates in the sarcolemma and deranges the membrane lipid environment during ischaemia. L-Palmitoylcarnitine chloride inhibits KATP channel activity, without affecting the single channel conductance, through interaction with Kir6.2[1].

Name	palmitoyl-l-carnitine chloride
Synonyms	MFCD00070346 Palmitoyl-L-carnitine chloride 3-carboxy-n,n,n-trimethyl-2-(palmitoyloxy)propan-1-aminium chloride UNII:EIL57224QR 1-Propanaminium, 3-carboxy-N,N,N-trimethyl-2-[(1-oxohexadecyl)oxy]-, chloride (1:1) EINECS 242-642-6 3-Carboxy-N,N,N-trimethyl-2-(palmitoyloxy)-1-propanaminium chloride

Description	L-Palmitoylcarnitine chloride, a long-chain acylcarnitine and a fatty acid metabolite, accumulates in the sarcolemma and deranges the membrane lipid environment during ischaemia. L-Palmitoylcarnitine chloride inhibits KATP channel activity, without affecting the single channel conductance, through interaction with Kir6.2[1].
Related Catalog	Research Areas >> Cardiovascular Disease Research Areas >> Metabolic Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
Target	Kir6.2 Human Endogenous Metabolite
In Vitro	L-Palmitoylcarnitine (1 µM) inhibits KATP channel activity, without affecting the single channel conductance, through interaction with Kir6.2. L-Palmitoylcarnitine simultaneously enhances the ATP sensitivity of the channel (IC50 fell from 62 to 30 µM)[1]. Modulation of the membrane lipid environment caused by L-Palmitoylcarnitine alters the KATP channel function mainly through the interaction with endogenous PI cascade, especially PIP2[1].
References	[1]. Haruna T, et al. Alteration of the membrane lipid environment by L-palmitoylcarnitine modulates K(ATP) channels in guinea-pig ventricular myocytes. Pflugers Arch. 2000;441(2-3):200-207.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	26-36
RIDADR	NONH for all modes of transport