946619-21-2

946619-21-2 structure

Name: MNI 137
Chemical Name: 2-Pyridinecarbonitrile, 4-(8-bromo-2,3-dihydro-2-oxo-1H-1,5-benzodiazepin-4-yl)
CAS Number: 946619-21-2
Molecular Formula: C₁₅H₉BrN₄O
Molecular Weight: 341.16200
Create Date: 2016-06-27 00:10:58
Modify Date: 2024-04-09 11:58:33
MNI137 is a potent and selective negative allosteric modulator for group II mGluRs. MNI137 has IC50s values of 8.3 and 12.6 nM for human and rat mGlu2 inhibition of glutamate-induced calcium mobilization[1].

Name	2-Pyridinecarbonitrile, 4-(8-bromo-2,3-dihydro-2-oxo-1H-1,5-benzodiazepin-4-yl)
Synonyms	MNI 137 VU 0360172 hydrochloride

Description	MNI137 is a potent and selective negative allosteric modulator for group II mGluRs. MNI137 has IC50s values of 8.3 and 12.6 nM for human and rat mGlu2 inhibition of glutamate-induced calcium mobilization[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> mGluR Research Areas >> Neurological Disease
References	[1]. Hemstapat K, et al. A novel family of potent negative allosteric modulators of group II metabotropic glutamate receptors. J Pharmacol Exp Ther. 2007;322(1):254-264.