555-30-6
555-30-6 structure
- Name: Methyldopa
- Chemical Name: α-methyl-L-dopa
- CAS Number: 555-30-6
- Molecular Formula: C10H13NO4
- Molecular Weight: 211.214
- Catalog: API Nervous system medication Anti-shock palsy
- Create Date: 2018-05-16 08:00:00
- Modify Date: 2024-01-02 12:49:46
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Methyldopa is an alpha-adrenergic agonist (selective for α2-adrenergic receptors) psychoactive drug used as a sympatholytic or antihypertensive.Target: alpha-adrenergic agonistMethyldopa is an alpha-adrenergic agonist (selective for α2-adrenergic receptors) psychoactive drug used as a sympatholytic or antihypertensive. Its use is now mostly deprecated following the introduction of alternative safer classes of agents. However, it continues to have a role in otherwise difficult to treat hypertension and gestational hypertension (also known as pregnancy-induced hypertension (PIH)).Methyldopa has a dual mechanism of action. It is a competitive inhibitor of the enzyme DOPA decarboxylase, also known as aromatic L-amino acid decarboxylase, which converts L-DOPA into dopamine. Dopamine is a precursor for norepinephrine (noradrenaline) and subsequently epinephrine (adrenaline). This inhibition results in reduced dopaminergic and adrenergic neurotransmission in the peripheral nervous system. This effect may lower blood pressure and cause central nervous system effects such as depression, anxiety, apathy, anhedonia, and parkinsonism. It is converted to α-methylnorepinephrine by dopamine beta-hydroxylase (DBH). α-methylnorepinephrine is an agonist of presynaptic central nervous system α2-adrenergic receptors. Activation of these receptors in the brainstem appears to inhibit sympathetic nervous system output and lower blood pressure. This is also the mechanism of action of clonidine.
| Name | α-methyl-L-dopa |
|---|---|
| Synonyms |
a-Methyl-L-dopa
α-Methyl-L-dopa Methyldopa Sesquihydrate Dopegyt L-(-)-b-(3,4-Dihydroxyphenyl)-a-methylalanine L-(-)-α-Methyl-β-(3,4-dihydroxyphenyl)alanine L-(-)-a-Methyl-b-(3,4-dihydroxyphenyl)alanine a-Methyl Dopa L-α-Methyl-DOPA alpha-methyl-L-dopa MFCD00004186 α-Methyl dopa EINECS 209-089-2 L-Tyrosine, 3-hydroxy-α-methyl-, hydrate (2:3) Tyrosine, 3-hydroxy-α-methyl-, hydrate (1:1) L-(a-Md) L-α-Methyldopa α-Methyldopa sesquihydrate (-)-α-Methyldopa 3-Hydroxy-α-methyl-L-tyrosine L-Tyrosine, 3-hydroxy-α-methyl- Dopamet (−)-3-(3,4-Dihydroxyphenyl)-2-methyl-L-alanine sesquihydrate 3-(3,4-Dihydroxyphenyl)-2-methyl-L-alanine,MK-351,Methyl-L-DOPA (S)-(-)-a-Methyldopa a-Methyl-b-(3,4-dihydroxyphenyl)-L-alanine Bayer 1440L Methyl dopa Aldomet (-)-3-(3,4-Dihydroxyphenyl)-2-Methyl-L-Alanine Sesquihydrate l-a-Methyldopa (S)-a-Methyldopa ALDORIL Alpha-Methyldopa Sesquihydrate Alanine, 3- (3,4-dihydroxyphenyl)-2-methyl-, L- Methyldopa 3-Hydroxy-α-methyltyrosine hydrate (1:1) L-a-Methyl-3,4-dihydroxyphenylalanine (-)-Methyldopa Elanpres |
| Description | Methyldopa is an alpha-adrenergic agonist (selective for α2-adrenergic receptors) psychoactive drug used as a sympatholytic or antihypertensive.Target: alpha-adrenergic agonistMethyldopa is an alpha-adrenergic agonist (selective for α2-adrenergic receptors) psychoactive drug used as a sympatholytic or antihypertensive. Its use is now mostly deprecated following the introduction of alternative safer classes of agents. However, it continues to have a role in otherwise difficult to treat hypertension and gestational hypertension (also known as pregnancy-induced hypertension (PIH)).Methyldopa has a dual mechanism of action. It is a competitive inhibitor of the enzyme DOPA decarboxylase, also known as aromatic L-amino acid decarboxylase, which converts L-DOPA into dopamine. Dopamine is a precursor for norepinephrine (noradrenaline) and subsequently epinephrine (adrenaline). This inhibition results in reduced dopaminergic and adrenergic neurotransmission in the peripheral nervous system. This effect may lower blood pressure and cause central nervous system effects such as depression, anxiety, apathy, anhedonia, and parkinsonism. It is converted to α-methylnorepinephrine by dopamine beta-hydroxylase (DBH). α-methylnorepinephrine is an agonist of presynaptic central nervous system α2-adrenergic receptors. Activation of these receptors in the brainstem appears to inhibit sympathetic nervous system output and lower blood pressure. This is also the mechanism of action of clonidine. |
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| Related Catalog | |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 441.6±45.0 °C at 760 mmHg |
| Melting Point | ≥300 °C |
| Molecular Formula | C10H13NO4 |
| Molecular Weight | 211.214 |
| Flash Point | 220.9±28.7 °C |
| Exact Mass | 211.084457 |
| PSA | 103.78000 |
| LogP | 0.13 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Index of Refraction | 1.635 |
| Storage condition | Store at RT |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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| Safety Phrases | S24/25 |
|---|---|
| WGK Germany | 3 |
| RTECS | YP2860000 |
| HS Code | 2918199090 |
| Precursor 6 | |
|---|---|
| DownStream 3 | |
![(3S,4R)-1-benzyl-3-[2-oxo-4(S)-phenyloxazolidinyl]-4-(3,4-dimethoxyphenyl)azetidin-2-one structure](https://image.chemsrc.com/caspic/496/111793-95-4.png)
![(3S,4R)-1-benzyl-3-methyl-3-[2-oxo-(4S)-phenyloxazolidinyl]-4-(3,4-dimethoxyphenyl)azetidin-2-one structure](https://image.chemsrc.com/caspic/458/111793-96-5.png)
![methyl-2 [(tri-O-benzoyl-2',3',5' β-D-ribofuranosyl)-3 hydroxy-4 phenyl]-3 alanine structure](https://image.chemsrc.com/caspic/029/79439-78-4.png)
| HS Code | 2918199090 |
|---|---|
| Summary | 2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0% |