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68-04-2

68-04-2 structure
68-04-2 structure
  • Name: Sodium citrate
  • Chemical Name: Sodium citrate
  • CAS Number: 68-04-2
  • Molecular Formula: C6H5Na3O7
  • Molecular Weight: 258.069
  • Catalog: Organic raw materials Organometallic compound Organic sodium
  • Create Date: 2018-02-04 08:00:00
  • Modify Date: 2024-01-02 07:06:01
  • Citric acid trisodium is a natural preservative and food tartness enhancer. Citric acid trisodium induces apoptosis and cell cycle arrest at G2/M phase and S phase. Citric acid trisodium cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid trisodium causes renal toxicity in mice[1][2][3].
Name Sodium citrate
Synonyms FEMA 3026
trisodium citrate
anhydrous sodium citrate
Na3-citrate
citnatin
citrosodna
citrosodina
MFCD00012462
natrocitral
citric acid trisodium salt
citreme
citrosodine
anhydrous trisodium citrate
Citric acid 3Na
EINECS 200-675-3
Description Citric acid trisodium is a natural preservative and food tartness enhancer. Citric acid trisodium induces apoptosis and cell cycle arrest at G2/M phase and S phase. Citric acid trisodium cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid trisodium causes renal toxicity in mice[1][2][3].
Related Catalog
In Vitro Citric acid trisodium (0-12.5 mM; 24 h) shows antiproliferative activity in a dose dependent manner[3]. Citric acid trisodium (12.5 mM; 72 h) induces apoptosis and cell cycle arrest at G2/M phase and S phase in a dosedependent manner[3]. Citric acid trisodium (12.5 mM; 48 h) increases the expression of FAS, BAX, BID, AIF, EndoG, cytochrome c, PARP, GADD153, GRP78 and caspase-3, -8, -9, and decreases of BCL-2 and BCL-Xl[3]. Cell Viability Assay[3] Cell Line: HaCaT cells Concentration: 0, 2.5, 5, 7.5, 10, 12.5 mM Incubation Time: 24 h Result: Inhibited the cell viability in a dose dependent manner. Cell Cycle Analysis[3] Cell Line: HaCaT cells Concentration: 12.5 mM Incubation Time: 0, 12, 24, 48, 72 h Result: Induced apoptosis and cell cycle arrest at G2/M phase and S phase in a dosedependent manner. Western Blot Analysis[3] Cell Line: HaCaT cells Concentration: 12.5 mM Incubation Time: 12, 24, 48 h Result: Increased the expression of FAS, BAX, BID, AIF, EndoG, cytochrome c, PARP, GADD153, GRP78 and caspase-3, -8, -9, and decreased of BCL-2 and BCL-Xl.
In Vivo Citric acid trisodium (120, 240, and 480 mg/kg; i.p.) significantly decreases GSH-Px activity and induces an increase in the MDA (malonyldialdehyde) levels in mouse liver[1]. Citric acid trisodium (120, 240, and 480 mg/kg; i.p.) induces apoptosis by increases caspase-3 activity in a dose-dependent manner in mouse hepatocytes[1]. Citric acid trisodium (120, 240, and 480 mg/kg; i.p.; weekly for 3 weeks) causes renal toxicity in mice[2]. Animal Model: 20 g male Kunming mice[2] Dosage: 120, 240, 480 mg/kg Administration: I.p.; weekly for 3 weeks Result: T-SOD and GSH-Px activities in the treated groups decreased with increasing doses of citric acid, NOS activity tended to increase, and H2O2 and MDA contents gradually decreased.
References

[1]. Chen X, et al. Study on injury effect of food additive citric acid on liver tissue in mice. Cytotechnology. 2014 Mar;66(2):275-82.

[2]. Chen X, Lv Q, Liu Y, Deng W. Effects of the food additive, citric acid, on kidney cells of mice. Biotech Histochem. 2015 Jan;90(1):38-44.

[3]. Ying TH, et al. Citric acid induces cell-cycle arrest and apoptosis of human immortalized keratinocyte cell line (HaCaT) via caspase- and mitochondrial-dependent signaling pathways. Anticancer Res. 2013 Oct;33(10):4411-20.
Density 1.008 g/mL at 20 °C
Melting Point 300°C
Molecular Formula C6H5Na3O7
Molecular Weight 258.069
Exact Mass 257.972839
PSA 140.62000
Storage condition 2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GE8300000
CHEMICAL NAME :
Citric acid, trisodium salt
CAS REGISTRY NUMBER :
68-04-2
LAST UPDATED :
199710
DATA ITEMS CITED :
9
MOLECULAR FORMULA :
C6-H5-O7.3Na
MOLECULAR WEIGHT :
258.08
WISWESSER LINE NOTATION :
QV1XQVQ1VQ &-NA- 3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1548 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 94,65,1948
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1364 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 94,65,1948
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
170 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 94,65,1948
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
449 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 94,65,1948 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 68905 No. of Facilities: 38675 (estimated) No. of Industries: 165 No. of Occupations: 97 No. of Employees: 200416 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - E0257 No. of Facilities: 403 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 4029 (estimated) No. of Female Employees: 2015 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 68905 No. of Facilities: 13473 (estimated) No. of Industries: 96 No. of Occupations: 105 No. of Employees: 301805 (estimated) No. of Female Employees: 163142 (estimated)
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi,C
Risk Phrases R22:Harmful if swallowed. R40:Limited evidence of a carcinogenic effect. R48/20/22:Harmful: danger of serious damage to health by prolonged exposure through inhalation and if swallowed .
Safety Phrases S36-S24/25
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS GE8300000
HS Code 2918150000
7440-70-2 structure

7440-70-2

~%

68-04-2 structure

68-04-2

Literature: Preiss-Bloom, Orahn; Attar, Ishay; Iram, Natalie; Komlos, Chagai; Haber, Meir Patent: US2011/110882 A1, 2011 ;
497-19-8 structure

497-19-8

~82%

68-04-2 structure

68-04-2

Literature: Romeo, G.; Lisi, F. Riv. Ital. Essenze-Profumi Piante Offic. Olii Vegetali-Saponi, 1935 , vol. 17, p. 310 - 312 Full Text Show Details Gmelin Handbook: Na: SVol.4, 39, page 1453 - 1455
77-92-9 structure

77-92-9

1310-73-2 structure

1310-73-2

~%

68-04-2 structure

68-04-2

Literature: Berthelot, M.; Louguinine, V. Ann. Chim. Phys., 1976 , vol. 9, p. 13 - 23 Full Text Show Details Massol, G. Ann. Chim. Phys., 1894 , vol. 1, p. 145 - 227 Full Text Show Details Gmelin Handbook: Na: SVol.4, 39, page 1453 - 1455 Full Text Show Details Thomsen, J. Thermochemische Untersuchungen, Stuttgart 1906, S. 58
HS Code 2918150000
Summary 2918150000. other salts and esters of citric acid. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:4ABXY(export license,certificate of inspection for goods inward,certificate of inspection for goods outwardexport license(processing trade),export license(border small volume trade)). MFN tariff:6.5%. General tariff:30.0%

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