129741-57-7

129741-57-7 structure

Name: Anemoside B4
Chemical Name: pulchinenoside b4
CAS Number: 129741-57-7
Molecular Formula: C₅₉H₉₆O₂₆
Molecular Weight: 1221.378
Catalog: Biochemical Plant extracts
Create Date: 2018-07-14 12:37:26
Modify Date: 2024-01-02 11:59:35
Anemoside B4 is Pulsatilla koreana Nakai that have many numerous biological effects in vitro, including enhancing hypoglycemic, anti-tumor, neuroprotective and anti-angiogenic activity. AB4 can inhibit the secretion of IL-10; SSA, SSD and PNS up-regulated IL-2 expression.[1] AB4, with IC50 value more than 390 ug/mL. Anemoside B4 inhibits cell proliferation.[2] Anemoside B4 can significantly suppress the secretion of the inflammatory factor E-selectin by endothelial cells. [3]

Name	pulchinenoside b4
Synonyms	6-Deoxy-α-L-mannopyranosyl-(1->4)-β-D-glucopyranosyl-(1->6)-1-O-[(3β)-3-{[2-O-(6-deoxy-α-L-mannopyranosyl)-α-L-arabinopyranosyl]oxy}-23-hydroxy-28-oxolup-20(29)-en-28-yl]-β-D-gluc opyranose β-D-Glucopyranose, O-6-deoxy-α-L-mannopyranosyl-(1->4)-O-β-D-glucopyranosyl-(1->6)-1-O-[(3β,18β)-3-[[2-O-(6-deoxy-α-L-mannopyranosyl)-α-L-arabinopyranosyl]oxy]-23-hydroxy-28-ox olup-20(29)-en-28-yl]- Anemoside B4 β-D-Glucopyranose, O-6-deoxy-α-L-mannopyranosyl-(1->4)-O-β-D-glucopyranosyl-(1->6)-1-O-[(3β)-3-[[2-O-(6-deoxy-α-L-mannopyranosyl)-α-L-arabinopyranosyl]oxy]-23-hydroxy-28-oxolup-20 (29)-en-28-yl]- 6-Deoxy-α-L-mannopyranosyl-(1->4)-β-D-glucopyranosyl-(1->6)-1-O-[(3β,18β)-3-{[2-O-(6-deoxy-α-L-mannopyranosyl)-α-L-arabinopyranosyl]oxy}-23-hydroxy-28-oxolup-20(29)-en-28-yl]-β -D-glucopyranose Anemoside B4,Pulchinenoside B4 Pulchinenoside C

Description	Anemoside B4 is Pulsatilla koreana Nakai that have many numerous biological effects in vitro, including enhancing hypoglycemic, anti-tumor, neuroprotective and anti-angiogenic activity. AB4 can inhibit the secretion of IL-10; SSA, SSD and PNS up-regulated IL-2 expression.[1] AB4, with IC50 value more than 390 ug/mL. Anemoside B4 inhibits cell proliferation.[2] Anemoside B4 can significantly suppress the secretion of the inflammatory factor E-selectin by endothelial cells. [3]
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Others Natural Products >> Terpenoids and Glycosides
References	[1]. Hu Y et al. Role of Chinese herbal medicinal ingredients in secretion of cytokines by PCV2-induced endothelial cells. J Immunotoxicol. 2016;13(2):141-7. [2]. Liu M et al. Cytotoxicity of the compounds isolated from Pulsatilla chinensis saponins and apoptosis induced by 23-hydroxybetulinic acid. Pharm Biol. 2015 Jan;53(1):1-9. [3]. Hu Y et al. Chinese herbal medicinal ingredients inhibit secretion of IL-6, IL-8, E-selectin and TXB2 in LPS-induced rat intestinal microvascular endothelial cells. Immunopharmacol Immunotoxicol. 2009;31(4):550-5.

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