19022-51-6

19022-51-6 structure

Name: Ophiobolin C
Chemical Name: ophiobolin C
CAS Number: 19022-51-6
Molecular Formula: C₂₅H₃₈O₃
Molecular Weight: 386.57
Catalog: Signaling Pathways Anti-infection HIV
Create Date: 2016-03-19 14:43:12
Modify Date: 2024-02-04 18:52:00
Ophiobolin C inhibits CCR5 binding to the envelop protein gp120 and CD4, which is responsible for mediating the entry of HIV-1 into cells[1]. Ophiobolin C is also cytotoxic to chronic lymphocytic leukemia cells[2].

Name	ophiobolin C
Synonyms	3-Hydroxy-5-oxoophiobola-7,19-dien-25-al Ophiobolin C-Triol

Description	Ophiobolin C inhibits CCR5 binding to the envelop protein gp120 and CD4, which is responsible for mediating the entry of HIV-1 into cells[1]. Ophiobolin C is also cytotoxic to chronic lymphocytic leukemia cells[2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> CCR Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection Signaling Pathways >> Immunology/Inflammation >> CCR
References	[1]. Jayasuriya H, et al. Isolation and structure of antagonists of chemokine receptor (CCR5). J Nat Prod. 2004 Jun;67(6):1036-8. [2]. Bladt TT, et al. Bio-activity and dereplication-based discovery of ophiobolins and other fungal secondary metabolites targeting leukemia cells. Molecules. 2013 Nov 26;18(12):14629-50.