Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 7-Ethoxy-4-methyl-2H-chromen-2-one
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Purity: 98.0%
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87-05-8

87-05-8 structure

87-05-8 structure

Name: Maraniol
Chemical Name: 7-Ethoxy-4-methylcoumarin
CAS Number: 87-05-8
Molecular Formula: C₁₂H₁₂O₃
Molecular Weight: 204.222
Catalog: Pharmaceutical intermediate Heterocyclic compound Pyridine compound Bromopyridine
Create Date: 2018-03-08 08:00:00
Modify Date: 2024-01-02 20:06:40
7-Ethoxy-4-methylcoumarin is a coumarin derivative and can be used as a substrate probe of mammalian cytochromes P450 1A1, 2B4 and 2B6[1][2].

Name	7-Ethoxy-4-methylcoumarin
Synonyms	Maraniol 7-ethoxy-4-methylchromen-2-one 2H-1-Benzopyran-2-one, 7-ethoxy-4-methyl- 7-Ethoxy-4-methyl-2H-chromen-2-one EINECS 201-721-5 MFCD00016971

Description	7-Ethoxy-4-methylcoumarin is a coumarin derivative and can be used as a substrate probe of mammalian cytochromes P450 1A1, 2B4 and 2B6[1][2].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450 Research Areas >> Others
Target	CYP1A1 CYP2B6 CYP2B4
References	[1]. Kuhn UD, et al. Induction of cytochrome P450 1A1 in rat liver slices by 7-ethoxycoumarin and 4-methyl-7-ethoxycoumarin. Exp Toxicol Pathol. 1998 Sep;50(4-6):491-6. [2]. Liu J, et al. Coumarin Derivatives as Substrate Probes of Mammalian Cytochromes P450 2B4 and 2B6: Assessing the Importance of 7-Alkoxy Chain Length, Halogen Substitution, and Non-Active Site Mutations. Biochemistry. 2016 Apr 5;55(13):1997-2007.

Density	1.2±0.1 g/cm3
Boiling Point	351.4±37.0 °C at 760 mmHg
Melting Point	114-116 °C(lit.)
Molecular Formula	C₁₂H₁₂O₃
Molecular Weight	204.222
Flash Point	146.2±21.1 °C
Exact Mass	204.078644
PSA	39.44000
LogP	2.90
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.548
Water Solubility	DMF: soluble

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi: Irritant;
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2932209090

621-34-1 structure

621-34-1

141-97-9 structure

141-97-9

~92%

87-05-8 structure

87-05-8

Literature: Synthetic Communications, , vol. 40, # 22 p. 3358 - 3364

90-33-5 structure

90-33-5

75-03-6 structure

75-03-6

~38%

87-05-8 structure

87-05-8

Literature: European Journal of Medicinal Chemistry, , vol. 77, p. 400 - 408

621-34-1 structure

621-34-1

4525-25-1 structure

4525-25-1

~98%

87-05-8 structure

87-05-8

Literature: Molecules, , vol. 10, # 3 p. 720 - 724

141-97-9 structure

141-97-9

108-46-3 structure

108-46-3

~%

87-05-8 structure

87-05-8

Literature: Asian Journal of Chemistry, , vol. 25, # 12 p. 6609 - 6611

31005-02-4 structure

31005-02-4

67-68-5 structure

67-68-5

~50%

87-05-8 structure

87-05-8

Literature: Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, , vol. 38, # 6 p. 726 - 727

90-33-5 structure

90-33-5

~%

87-05-8 structure

87-05-8

Literature: US1934361 , ;

Precursor 8
621-34-1 141-97-9 90-33-5 75-03-6
4525-25-1 108-46-3 31005-02-4 67-68-5
DownStream 1
24535-08-8

HS Code	2932209090
Summary	2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%