4551-00-2
4551-00-2 structure
- Name: SOS1-IN-1
- Chemical Name: 9-[3-(2-nitrophenyl)prop-2-enylidene]fluorene
- CAS Number: 4551-00-2
- Molecular Formula: C22H15NO2
- Molecular Weight: 325.36000
- Catalog: Research Areas Others
- Create Date: 2016-02-17 15:19:58
- Modify Date: 2024-01-11 19:45:15
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SOS1-IN-1 is a SOS1 inhibitor.
| Name | 9-[3-(2-nitrophenyl)prop-2-enylidene]fluorene |
|---|
| Description | SOS1-IN-1 is a SOS1 inhibitor. |
|---|---|
| Related Catalog | |
| Target |
SOS1[1]. |
| In Vitro | The growth inhibitory rate (IR)=(average OD value in the control group-average OD value in the treatment group)/average OD value in the control group×100% are compared. Treatments with SOS1-IN-1 at 40 μM and NSC-658497 at 30 μM result in growth inhibitory rate of 29% and 8% respectively. The combination treatment results in growth inhibitory rate of 54%, showing the synergistic effect of SOS1-IN-1 and NSC-658497 on cell growth inhibition. It is showed that the treatment with NSC-658497 at 40 μM for 2 hours alone or in combìnation with the treatment with 40 μM of SOS1-IN-1 overnight resulted in lower expression levels of P-AKT and P-ERK. The treatment wlth 40 μM of SOS1-IN-1 overnight resulted in lower expression levels of P-ERK[1]. |
| Cell Assay | MIA paca-2 cells (KRAS G12 C) are subjected to a 3-day proliferation assay following treatment with SOS1-IN-1 (NSC-70220: 40 μM), treatment with NSC-658497 (30 μM) and treatment with a combination of SOS1-IN-1 (40 μM) and NSC-658497 (30 μM). DMSO is used as the negative control[1]. |
| References |
| Density | 1.321g/cm3 |
|---|---|
| Boiling Point | 569.6ºC at 760 mmHg |
| Molecular Formula | C22H15NO2 |
| Molecular Weight | 325.36000 |
| Flash Point | 274.9ºC |
| Exact Mass | 325.11000 |
| PSA | 45.82000 |
| LogP | 6.24350 |
| Index of Refraction | 1.767 |
|
~%
4551-00-2 |
| Literature: Kuhn; Winterstein Helvetica Chimica Acta, 1928 , vol. 11, p. 113 Helvetica Chimica Acta, 1929 , vol. 12, p. 493 |
