97151-02-5

97151-02-5 structure

Name: α-Hydroxytamoxifen
Chemical Name: (E)-4-[4-[2-(dimethylamino)ethoxy]phenyl]-3,4-diphenylbut-3-en-2-ol
CAS Number: 97151-02-5
Molecular Formula: C₂₆H₂₉NO₂
Molecular Weight: 387.51400
Catalog: Research Areas Cancer
Create Date: 2017-07-08 05:54:20
Modify Date: 2024-01-10 19:15:31
α-Hydroxytamoxifen is a metabolite of tamoxifen, reacts with DNA in the absence of metabolizing enzymes, and causes formation of DNA adducts[1].

Name	(E)-4-[4-[2-(dimethylamino)ethoxy]phenyl]-3,4-diphenylbut-3-en-2-ol
Synonyms	trans-(E)-4-[4-(2-dimethylamino-ethoxy)-phenyl]-3,4-diphenyl-but-3-en-2-ol (E)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-1,2-diphenyl-1-buten-3-ol Trans-Hydroxy-Tamoxifen (E)-\|A-Hydroxy Tamoxifen

Description	α-Hydroxytamoxifen is a metabolite of tamoxifen, reacts with DNA in the absence of metabolizing enzymes, and causes formation of DNA adducts[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. Phillips DH, et al. alpha-Hydroxytamoxifen, a metabolite of tamoxifen with exceptionally high DNA-binding activity in rat hepatocytes. Cancer Res. 1994 Nov 1;54(21):5518-22.

HS Code	2922509090

61923-53-3

97151-02-5

Literature: Journal of Medicinal Chemistry, , vol. 28, # 10 p. 1491 - 1497

19118-19-5

19957-51-8

97151-02-5

97170-41-7

Literature: Journal of Medicinal Chemistry, , vol. 28, # 10 p. 1491 - 1497

19118-19-5

75-07-0

19957-51-8

97151-02-5

Detail

Literature: Journal of Medicinal Chemistry, , vol. 28, # 10 p. 1491 - 1497

Precursor 3
61923-53-3 19118-19-5 75-07-0
DownStream 0

HS Code	2922509090
Summary	2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%