194093-42-0

194093-42-0 structure

Name: Pumosetrag Hydrochloride
Chemical Name: N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]-7-oxo-4H-thieno[3,2-b]pyridine-6-carboxamide,hydrochloride
CAS Number: 194093-42-0
Molecular Formula: C₁₅H₁₈ClN₃O₂S
Molecular Weight: 339.840
Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
Create Date: 2018-12-29 18:59:48
Modify Date: 2024-01-09 11:24:45
Pumosetrag Hydrochloride (MKC-733; DDP-733) is an orally available 5-HT3 partial agonist developed for the treatment of irritable bowel syndrome and gastroesophageal reflux disease.

Name	N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]-7-oxo-4H-thieno[3,2-b]pyridine-6-carboxamide,hydrochloride
Synonyms	N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-7-oxo-4,7-dihydrothieno[3,2-b]pyridine-6-carboxamide hydrochloride (1:1) Pumosetraghydrochloride (R)-N-(1-azabicyclo[2.2.2]oct-3-yl)-7-oxo-4,7-dihydrothieno-[3,2-b]pyridine-6-carboxamide hydrochloride UNII-UVW44TKU66 (R)-N-(3-Quinuclidinyl)-7-oxo-dihydrothieno(3,2b)pyridine-6-carboxamide hydrochloride (R)-N-(1-azabicyclo[2.2.2]oct-3-yl)-4,7-dihydro-7-oxo-thieno[3,2-b]pyridine-6-carboxamide hydrochloride Thieno[3,2-b]pyridine-6-carboxamide, N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-4,7-dihydro-7-oxo-, hydrochloride (1:1) DPP 733 (R)-N-1-azabicyclo[2.2.2]oct-3-yl-4,7-dihydro-7-oxothieno[3,2-b]pyridine-6-carboxamide monohydrochloride (R)-N-(3-quinuclidinyl)-7-oxo-4,7-dihydrothieno[3,2-b]pyridine-6-carboxamide hydrochloride Pumosetrag Hydrochloride

Description	Pumosetrag Hydrochloride (MKC-733; DDP-733) is an orally available 5-HT3 partial agonist developed for the treatment of irritable bowel syndrome and gastroesophageal reflux disease.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Research Areas >> Metabolic Disease
Target	5-HT3[1]
In Vivo	Pumosetrag displays both regional and species specificities. Pumosetrag has a lower efficacy than 5-HT in the rat jejunum, ileum and distal colon; however, it has similar efficacy and potency to 5-HT in the rat proximal colon. The activity profile of Pumosetrag is different in the guinea pig intestine where it exhibits greater potency and efficacy than 5-HT in all regions. Pumosetrag shows little to no response in the regions of the mouse intestine. Responses to Pumosetrag in the rat and guinea pig tissues are inhibited by ondansetron, confirming its action on 5-HT(3) receptors[1]. Pumosetrag delays liquid gastric emptying in association with relaxation of the proximal stomach, stimulates fasting antroduodenal migrating motor complex activity and accelerates small intestinal transit[2].
References	[1]. Chetty N, et al. Effects of the novel 5-HT3 agonist MKC-733 on the rat, mouse and guinea pig digestive tract. Pharmacology. 2008;81(2):104-9. Epub 2007 Oct 19. [2]. Coleman NS, et al. Effect of a novel 5-HT3 receptor agonist MKC-733 on upper gastrointestinal motility in humans. Aliment Pharmacol Ther. 2003 Nov 15;18(10):1039-48.

Boiling Point	529.9ºC at 760mmHg
Molecular Formula	C₁₅H₁₈ClN₃O₂S
Molecular Weight	339.840
Flash Point	274.3ºC
Exact Mass	339.080811
PSA	96.93000
LogP	2.72830
Vapour Pressure	2.59E-11mmHg at 25°C
Storage condition	2-8℃

RIDADR	NONH for all modes of transport

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