Shanghai Nianxing Industrial Co., Ltd
China
Product Name: BMS 753
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

DC Chemicals Limited
China
Product Name: BMS-753
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

ShangHai DC Chemicals Co.,Ltd
China
Product Name: BMS-753
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Lai

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]-benzoic acid
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

215307-86-1

215307-86-1 structure

215307-86-1 structure

Name: BMS 753
Chemical Name: 4-{[(1,1,3,3-Tetramethyl-2-oxo-2,3-dihydro-1H-inden-5-yl)carbonyl ]amino}benzoic acid
CAS Number: 215307-86-1
Molecular Formula: C₂₁H₂₁NO₄
Molecular Weight: 351.39600
Catalog: Signaling Pathways Metabolic Enzyme/Protease RAR/RXR
Create Date: 2017-03-16 09:37:31
Modify Date: 2024-01-09 21:45:06
BMS 753 is an isotype-selective retinoic acid receptor α (RARα) agonist, with a Ki of 2 nM[1].

Name	4-{[(1,1,3,3-Tetramethyl-2-oxo-2,3-dihydro-1H-inden-5-yl)carbonyl ]amino}benzoic acid
Synonyms	Pentanoic acid,5-[[bis(diethoxyphosphinyl)methyl]amino]-5-oxo 4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino] benzoic acid 4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]-benzoic acid 4-[(Z)-2-ethoxyvinyl]-2-(methylthio)-5-pyrimidinecarbonitrile 4-[(tetraethylbisphosphonomethyl)carbamoyl]butanoic acid

Description	BMS 753 is an isotype-selective retinoic acid receptor α (RARα) agonist, with a Ki of 2 nM[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Metabolic Enzyme/Protease >> RAR/RXR
Target	RARα
In Vitro	BMS 753 results in low levels of RARβ transcripts in WT cells, RARγ-/-, but not activates in RARa-/- cells[1].
References	[1]. M Géhin, et al. Structural basis for engineering of retinoic acid receptor isotype-selective agonists and antagonists. Chem Biol. 1999 Aug;6(8):519-29. [2]. R Taneja, et al. Cell-type and promoter-context dependent retinoic acid receptor (RAR) redundancies for RAR beta 2 and Hoxa-1 activation in F9 and P19 cells can be artefactually generated by gene knockouts. Proc Natl Acad Sci U S A. 1996 Jun 11; 93(12): 6197–6202.

Molecular Formula	C₂₁H₂₁NO₄
Molecular Weight	351.39600
Exact Mass	351.14700
PSA	83.47000
LogP	3.84800

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
RIDADR	NONH for all modes of transport