104756-72-1
104756-72-1 structure
- Name: TA-7552
- Chemical Name: dimethyl 4-(3,4-dimethoxyphenyl)-1-hydroxy-5,6,7-trimethoxynaphthalene-2,3-dicarboxylate
- CAS Number: 104756-72-1
- Molecular Formula: C25H26O10
- Molecular Weight: 486.46800
- Catalog: Research Areas Cardiovascular Disease
- Create Date: 2017-04-07 21:45:34
- Modify Date: 2024-01-22 17:53:02
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TA-7552 is a potent cholesterol-lowering agent.
| Name | dimethyl 4-(3,4-dimethoxyphenyl)-1-hydroxy-5,6,7-trimethoxynaphthalene-2,3-dicarboxylate |
|---|---|
| Synonyms |
ta 7552
TA-7552 |
| Description | TA-7552 is a potent cholesterol-lowering agent. |
|---|---|
| Related Catalog | |
| In Vivo | TA-7552 is a potent cholesterol-lowering agent. When TA-7552 is mixed with unsupplemented CLEA CE-2 powder in a concentration of 0.05% and administered to rats for 7 days, TA-7552 does not reduce the normal level of serum cholesterol. The hypocholesterolemic effect of TA-7552 is apparent at the lowest concentration (0.01%) of the drug in the diet, corresponding to a daily dose of ~10 mg/kg body weight, and maximal at the highest concentration of 0.2% TA-7552, lowering serum total cholesterol by 72% while elevating serum HDL cholesterol by 88%. TA-7552 also dose dependently suppresses this rise of hepatic cholesterol, and its lowering rate at the maximal dose is 90%[1]. |
| Animal Admin | Male Sprague-Dawley rats (4 weeks of age) are used in this experiment. In the mechanism study, rats are divided into two or three groups of 4 to 6 animals so that the mean body weight, which varies from 210 g to 330 g, is similar between the groups. The experimental groups are treated with TA-7552 (0.1% in CE-2 powder) or cholestyramine (5% in CE-2 powder) by feeding the diet ad libitum for a period of time; The control groups are fed CE-2 powder. When the feces are collected, the animals are individually housed in a metabolic cage, and the collected feces are lyophylized and stored at -20°C[1]. |
| References |
| Density | 1.269g/cm3 |
|---|---|
| Boiling Point | 592.3ºC at 760mmHg |
| Molecular Formula | C25H26O10 |
| Molecular Weight | 486.46800 |
| Flash Point | 195ºC |
| Exact Mass | 486.15300 |
| PSA | 118.98000 |
| LogP | 3.82860 |
| Vapour Pressure | 1.26E-14mmHg at 25°C |
| Index of Refraction | 1.58 |
| Storage condition | 2-8℃ |