193681-12-8
193681-12-8 structure
- Name: alamifovir
- Chemical Name: alamifovir
- CAS Number: 193681-12-8
- Molecular Formula: C19H20F6N5O5PS
- Molecular Weight: 575.42200
- Catalog: Signaling Pathways Anti-infection HBV
- Create Date: 2018-07-14 00:02:08
- Modify Date: 2024-01-10 08:05:50
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Alamifovir (LY582563; MCC-478), a purine nucleotide analogue prodrug, shows potent activity against wild type and lamivudine resistant hepatitis B virus (HBV). Alamifovir has high activity against HBV replication and sustained antiviral effect[1][2].
| Name | alamifovir |
|---|---|
| Synonyms | mcc 478 |
| Description | Alamifovir (LY582563; MCC-478), a purine nucleotide analogue prodrug, shows potent activity against wild type and lamivudine resistant hepatitis B virus (HBV). Alamifovir has high activity against HBV replication and sustained antiviral effect[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | MCC-478 (0-10 μM) 对野生型 HBV 的 EC50 为 0.027 μM，对 M552I 为 2.6 μM，对 M552V 为 3.3 μM，对 L528M/M552V 为 2.0 μM[ 1]。 |
| References |
| Density | 1.61g/cm3 |
|---|---|
| Boiling Point | 635.9ºC at 760mmHg |
| Molecular Formula | C19H20F6N5O5PS |
| Molecular Weight | 575.42200 |
| Flash Point | 338.4ºC |
| Exact Mass | 575.08300 |
| PSA | 158.72000 |
| LogP | 5.47450 |
| Vapour Pressure | 4.51E-16mmHg at 25°C |
| Index of Refraction | 1.582 |
