80-74-0

80-74-0 structure

Name: sulfisoxazole acetyl (200 mg)
Chemical Name: N-(4-aminophenyl)sulfonyl-N-(3,4-dimethyl-1,2-oxazol-5-yl)acetamide
CAS Number: 80-74-0
Molecular Formula: C₁₃H₁₅N₃O₄S
Molecular Weight: 309.34100
Catalog: API Synthetic anti-infective drugs Sulfonamides and synergists
Create Date: 2018-04-21 08:00:00
Modify Date: 2024-01-02 15:07:17
Sulfisoxazole acetyl (N1-Acetylsulfisoxazole), a Sulfisoxazole derivative, is an orally active dihydropteroate synthase inhibitor. Sulfisoxazole acetyl has an antibacterial action[1].

Name	N-(4-aminophenyl)sulfonyl-N-(3,4-dimethyl-1,2-oxazol-5-yl)acetamide
Synonyms	GANTRISIN PEDIATRIC Acetyl-(3,4-dimethyl-isoxazol-5-yl)-sulfanilyl-amin Sulfisoxazole acetyl Lipo Gantrisin N-(4-amino-benzenesulfonyl)-N-(3,4-dimethyl-isoxazol-5-yl)-acetamide N-3,4-dimethylisoxazol-5-yl-N-sulfanilylacetamide UNII-WBT5QH3KED EINECS 201-305-3 Sulfisoxazole acetal acetylsulfafurazole ACETYL SULFISOXAZOLE

Description	Sulfisoxazole acetyl (N1-Acetylsulfisoxazole), a Sulfisoxazole derivative, is an orally active dihydropteroate synthase inhibitor. Sulfisoxazole acetyl has an antibacterial action[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	As with other sulfonamides, the antibacterial action of Sulfisoxazole acetyl (N1-Acetylsulfisoxazole) is attributable to inhibiting dihydropteroate synthase, a key enzyme in folate synthesis in bacteria. Sulfisoxazole acetyl is known to be transformed primarily to sulfisoxazole, partly to N4-acetyl sulfisoxazole (N4AS), and likely also to diacetyl sulfisoxazole (DAS) and other compounds[1].
References	[1]. Eunyoung Kim, et al. Simultaneous determination of N(1)-acetyl sulfisoxazole and its metabolites, and relative bioavailability compare to sulfisoxazole in rats. J Pharm Biomed Anal. 2016 Sep 10;129:117-120.

RIDADR	NONH for all modes of transport
HS Code	2935009090

127-69-5

108-24-7

80-74-0

Literature: Shionogi Kenkyusho Nenpo, , # 5 p. 32,35 Chem.Abstr., , p. 16750 DE945238 , ; US2721200 , ;

Precursor 2
127-69-5 108-24-7
DownStream 0

HS Code	2935009090
Summary	2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%