88986-89-4

88986-89-4 structure

Name: 2-Propanone, 1-(2-methoxyethoxy)- (9CI)
Chemical Name: 1-(2-methoxyethoxy)propan-2-one
CAS Number: 88986-89-4
Molecular Formula: C₆H₁₂O₃
Molecular Weight: 132.15800
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2017-04-24 14:29:58
Modify Date: 2024-01-09 16:51:55
PROTAC Linker 28 is a PROTAC linker, which refers to the alkyl chain composition. PROTAC Linker 28 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Name	1-(2-methoxyethoxy)propan-2-one
Synonyms	2-Propanone,1-(2-methoxyethoxy) 1-(2-methoxyethoxy)acetone (2-Methoxy-aethoxy)-aceton (2-methoxy-ethoxy)-acetone

Description	PROTAC Linker 28 is a PROTAC linker, which refers to the alkyl chain composition. PROTAC Linker 28 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Alkyl/ether
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

HS Code	2914509090

109-86-4

75-56-9

88986-89-4

Literature: Dow Chem.Co. Patent: US2526545 , 1948 ;

Precursor 2
109-86-4 75-56-9
DownStream 0

HS Code	2914509090
Summary	HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%