202402-01-5
202402-01-5 structure
- Name: GET73
- Chemical Name: 4-methoxy-N-[[4-(trifluoromethyl)phenyl]methyl]butanamide
- CAS Number: 202402-01-5
- Molecular Formula: C13H16F3NO2
- Molecular Weight: 275.26700
- Catalog: Research Areas Neurological Disease
- Create Date: 2016-03-29 10:24:43
- Modify Date: 2024-03-10 18:23:07
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GET73 is a γ-hydroxybutyric acid (GHB) analog, a naturally occurring neurotransmitter. GET73 has anti-alcohol and anxiolytic properties. GET73 significantly affects glutamate transmission in the hippocampus[1][2][3].
| Name | 4-methoxy-N-[[4-(trifluoromethyl)phenyl]methyl]butanamide |
|---|---|
| Synonyms |
UNII-U5CLZ223FH
GET 73 4-Methoxy-N-((4-(trifluoromethyl)phenyl)methyl)-butanamide |
| Description | GET73 is a γ-hydroxybutyric acid (GHB) analog, a naturally occurring neurotransmitter. GET73 has anti-alcohol and anxiolytic properties. GET73 significantly affects glutamate transmission in the hippocampus[1][2][3]. |
|---|---|
| Related Catalog | |
| In Vitro | GET73 (1 µM, 10 µM; 1 hour) 1 hour before and during chronic ethanol exposure prevents ethanol-induced a reduction of cell viability, an alteration of cytoskeleton, a decrease in extracellular glutamate levels and an increase of reactive oxygen species production[1]. Cell Viability Assay[1] Cell Line: Rat hippocampal neurons Concentration: 0.1 µM, 1 µM, 10 µM Incubation Time: 1 hour Result: Prevented the ethanol (75 mM, 4 days) -induced MTT reduction. |
| In Vivo | GET73 (5–50 mg/kg; i.g.) exerts an anxiolytic effect in Sprague-Dawley rats exposed to the elevated plus maze (EPM) test[3]. Animal Model: Male SD rats (200-300 g and 300–350 g)[3] Dosage: 5 mg/kg, 10 mg/kg, 25 mg/kg, 50 mg/kg Administration: Oral gavage Result: Exerted an anxiolytic effect in rats exposed to the elevated plus maze (EPM) test. |
| References |
| Molecular Formula | C13H16F3NO2 |
|---|---|
| Molecular Weight | 275.26700 |
| Exact Mass | 275.11300 |
| PSA | 41.82000 |
| LogP | 3.58850 |
| Hazard Codes | Xi |
|---|