202402-01-5

202402-01-5 structure

Name: GET73
Chemical Name: 4-methoxy-N-[[4-(trifluoromethyl)phenyl]methyl]butanamide
CAS Number: 202402-01-5
Molecular Formula: C₁₃H₁₆F₃NO₂
Molecular Weight: 275.26700
Catalog: Research Areas Neurological Disease
Create Date: 2016-03-29 10:24:43
Modify Date: 2024-03-10 18:23:07
GET73 is a γ-hydroxybutyric acid (GHB) analog, a naturally occurring neurotransmitter. GET73 has anti-alcohol and anxiolytic properties. GET73 significantly affects glutamate transmission in the hippocampus[1][2][3].

Name	4-methoxy-N-[[4-(trifluoromethyl)phenyl]methyl]butanamide
Synonyms	UNII-U5CLZ223FH GET 73 4-Methoxy-N-((4-(trifluoromethyl)phenyl)methyl)-butanamide

Description	GET73 is a γ-hydroxybutyric acid (GHB) analog, a naturally occurring neurotransmitter. GET73 has anti-alcohol and anxiolytic properties. GET73 significantly affects glutamate transmission in the hippocampus[1][2][3].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vitro	GET73 (1 µM, 10 µM; 1 hour) 1 hour before and during chronic ethanol exposure prevents ethanol-induced a reduction of cell viability, an alteration of cytoskeleton, a decrease in extracellular glutamate levels and an increase of reactive oxygen species production[1]. Cell Viability Assay[1] Cell Line: Rat hippocampal neurons Concentration: 0.1 µM, 1 µM, 10 µM Incubation Time: 1 hour Result: Prevented the ethanol (75 mM, 4 days) -induced MTT reduction.
In Vivo	GET73 (5–50 mg/kg; i.g.) exerts an anxiolytic effect in Sprague-Dawley rats exposed to the elevated plus maze (EPM) test[3]. Animal Model: Male SD rats (200-300 g and 300–350 g)[3] Dosage: 5 mg/kg, 10 mg/kg, 25 mg/kg, 50 mg/kg Administration: Oral gavage Result: Exerted an anxiolytic effect in rats exposed to the elevated plus maze (EPM) test.
References	[1]. Tomasini MC, et al. GET73 Prevents Ethanol-Induced Neurotoxicity in Primary Cultures of Rat Hippocampal Neurons. Alcohol Alcohol. 2016 Mar;51(2):128-35. [2]. Ferraro L, et al. GET73 modulates rat hippocampal glutamate transmission: evidence for a functional interaction with mGluR5. Pharmacol Rep. 2011;63(6):1359-71. [3]. Loche A, et al. Anti-Alcohol and Anxiolytic Properties of a New Chemical Entity, GET73. Front Psychiatry. 2012 Feb 14;3:8.

Molecular Formula	C₁₃H₁₆F₃NO₂
Molecular Weight	275.26700
Exact Mass	275.11300
PSA	41.82000
LogP	3.58850

Hazard Codes	Xi

56-41-7	108-65-6
56-35-9	64-17-5
67-56-1	108-88-3
141-78-6	1310-73-2
13463-67-7	1333-86-4