- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: Choline glycerophosphate
- Price:
- Purity: 98.0%
- Stocking Period: 10 Day
- Contact: Yang
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Choline glycerophosphate
- Price: ￥958.0/5g ￥328.0/1g
- Purity: 98.0%
- Stocking Period: 2 Day
- Contact: Liu jia
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: Choline Alfoscerate
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Stocking Period: 1 Day
- Contact: Tony Lai
- DC Chemicals Limited
- China
- Product Name: Choline Alfoscerate
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: Choline glycerophosphate
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
28319-77-9
28319-77-9 structure
- Name: Choline glycerophosphate
- Chemical Name: choline alfoscerate
- CAS Number: 28319-77-9
- Molecular Formula: C8H20NO6P
- Molecular Weight: 257.221
- Catalog: API Nervous system medication Cholinergic
- Create Date: 2018-05-31 08:00:00
- Modify Date: 2024-01-02 21:03:26
-
L-Alpha glycerylphosphorylcholine (alpha-GPC, choline alfoscerate) is a natural choline compound found in the brain and in milk. It is also a parasympathomimetic acetylcholine precursor which may have potential for the treatment of Alzheimer's disease and dementia.IC50 value:Target: Anti-ADAlpha-GPC rapidly delivers choline to the brain across the blood–brain barrier and is a biosynthetic precursor of the acetylcholine neurotransmitter. It is a non-prescription drug in most countries due to its Generally Recognised As Safe (GRAS) status [1]. Studies have investigated its efficacy for cognitive disorders including stroke and Alzheimer’s disease. An Italian multicentre clinical trial on 2,044 patients suffering from recent stroke were supplied alpha-GPC in doses of 1,000 mg/day for 28 days and 400 mg three times per day for the five ensuing months. The trial confirmed the therapeutic role of alpha-GPC on the cognitive recovery of patients based on four measurement scales, three of which reached statistical significance [2].
| Name | choline alfoscerate |
|---|---|
| Synonyms |
L-α-Glycerophosphocholine
α-GPC Ethanaminium, 2-[[[(2R)-2,3-dihydroxypropoxy]hydroxyphosphinyl]oxy]-N,N,N-trimethyl-, inner salt L-a-Glycerylphosphorylcholine L-α-Glycerophosphorylcholine Choline Alfoscerate cholini alfosceras (R)-2-[[(2,3-Dihydroxypropoxy)hydroxyphosphinyl]oxy]-N,N,N-trimethylethanaminium hydroxide inner salt sn-Glycero-3-phosphocholine (2R)-2,3-Dihydroxypropyl 2-(trimethylammonio)ethyl phosphate MFCD00063544 alfoscerato de colina EINECS 248-962-2 alfoscerate de choline L-α Glycerylphosphorylcholine L-a-GPC sn-Glycero-3-phosphorylcholine Choline glycerophosphate |
| Description | L-Alpha glycerylphosphorylcholine (alpha-GPC, choline alfoscerate) is a natural choline compound found in the brain and in milk. It is also a parasympathomimetic acetylcholine precursor which may have potential for the treatment of Alzheimer's disease and dementia.IC50 value:Target: Anti-ADAlpha-GPC rapidly delivers choline to the brain across the blood–brain barrier and is a biosynthetic precursor of the acetylcholine neurotransmitter. It is a non-prescription drug in most countries due to its Generally Recognised As Safe (GRAS) status [1]. Studies have investigated its efficacy for cognitive disorders including stroke and Alzheimer’s disease. An Italian multicentre clinical trial on 2,044 patients suffering from recent stroke were supplied alpha-GPC in doses of 1,000 mg/day for 28 days and 400 mg three times per day for the five ensuing months. The trial confirmed the therapeutic role of alpha-GPC on the cognitive recovery of patients based on four measurement scales, three of which reached statistical significance [2]. |
|---|---|
| Related Catalog | |
| Target |
Human Endogenous Metabolite |
| References |
| Melting Point | -98ºC |
|---|---|
| Molecular Formula | C8H20NO6P |
| Molecular Weight | 257.221 |
| Flash Point | 11 °C |
| Exact Mass | 257.102814 |
| PSA | 108.86000 |
| LogP | -5.63 |
| Appearance | solid |
| Index of Refraction | 1.329 (20ºC) |
| Storage condition | −20°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
| Hazard Codes | F: Flammable;T: Toxic; |
|---|---|
| Risk Phrases | R11 |
| Safety Phrases | S16-S36/37-S45 |
| RIDADR | UN 1230 3/PG 2 |
| WGK Germany | 2 |
| RTECS | KH2775000 |
| Packaging Group | II |
| HS Code | 2923900090 |
|
~92%
28319-77-9 |
| Literature: Park, Jong Moon; De Castro, Kathlia A.; Ahn, Hyunseok; Rhee, Hakjune Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 9 p. 2689 - 2691 |
|
~%
28319-77-9 |
| Literature: Nakamura, Yuichi; Kato, Hikaru; Nishikawa, Tadateru; Iwasaki, Noriyuki; Suwa, Yoshiaki; Rotinsulu, Henki; Losung, Fije; Maarisit, Wilmar; Mangindaan, Remy E. P.; Morioka, Hiroshi; Yokosawa, Hideyoshi; Tsukamoto, Sachiko Organic Letters, 2013 , vol. 15, # 2 p. 322 - 325 |
| HS Code | 2923900090 |
|---|---|
| Summary | 2923900090 other quaternary ammonium salts and hydroxides。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0% |