1217625-71-2

1217625-71-2 structure

Name: Mecamylamine-d3 hydrochloride
Chemical Name: (1R,3R,4S)-2,2,3-trimethyl-N-(trideuteriomethyl)bicyclo[2.2.1]heptan-3-amine,hydrochloride
CAS Number: 1217625-71-2
Molecular Formula: C₁₁H₁₉ClD₃N
Molecular Weight: 206.77100
Catalog: Signaling Pathways Membrane Transporter/Ion Channel nAChR
Create Date: 2017-01-23 23:57:05
Modify Date: 2024-01-13 14:31:51
Mecamylamine-d3 hydrochloride is the deuterium labeled Mecamylamine hydrochloride. Mecamylamine hydrochloride is an orally active, nonselective, noncompetitive nAChR antagonist that can treat various neuropsychiatric disorders. Mecamylamine hydrochloride is originally used as a ganglionic blocker in treating hypertension. Mecamylamine hydrochloride can easily crosses the blood-brain barrier[1][2].

Name	(1R,3R,4S)-2,2,3-trimethyl-N-(trideuteriomethyl)bicyclo[2.2.1]heptan-3-amine,hydrochloride
Synonyms	Mecamine-d3 Mecamylamine-d3 Hydrochloride N,2,3,3-Tetramethyl-bicyclo[2.2.1]heptan-2-amine-d3 Hydrochloride Inversine-d3 Mevasine-d3 N,2,3,3-Tetramethyl-2-norbornanamine-d3 Hydrochloride Mevasin-d3 CPDD 0059-d3

Description	Mecamylamine-d3 hydrochloride is the deuterium labeled Mecamylamine hydrochloride. Mecamylamine hydrochloride is an orally active, nonselective, noncompetitive nAChR antagonist that can treat various neuropsychiatric disorders. Mecamylamine hydrochloride is originally used as a ganglionic blocker in treating hypertension. Mecamylamine hydrochloride can easily crosses the blood-brain barrier[1][2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR Research Areas >> Neurological Disease
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Bacher I, et al. Mecamylamine - a nicotinic acetylcholine receptor antagonist with potential for the treatment of neuropsychiatric disorders. Expert Opin Pharmacother. 2009 Nov;10(16):2709-21. [3]. Ostroumov K, et al. Modeling study of mecamylamine block of muscle type acetylcholine receptors. Eur Biophys J. 2008 Apr;37(4):393-402. [4]. Rabenstein RL, et al. The nicotinic antagonist mecamylamine has antidepressant-like effects in wild-type but not beta2- or alpha7-nicotinic acetylcholine receptor subunit knockout mice. Psychopharmacology (Berl). 2006 Dec;189(3):395-401.

Molecular Formula	C₁₁H₁₉ClD₃N
Molecular Weight	206.77100
Exact Mass	206.16300
PSA	12.03000
LogP	3.61350

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