Name | α-Tocopheryl Succinate |
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Synonyms |
a-Tocopheryl Succinate
Butanedioic Acid (2R-(2R*(4R*,8R*)))-mono(3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl) Ester a-Tocopheryl Acid Succinate α-Tocopheryl acid succinate (+)-α-Tocopheryl succinate VES EINECS 224-403-8 D-α-Tocopherol succinate (+)-2,5,7,8-Tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chromanyl Hydrogen Succinate a-Tocopherol Acid Succinate mono((2R)-3,4-dihydro-2,5,7,8-tetramethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl) butanedioate Butanedioic acid Mono((2R)-3,4-dihydro-2,5,7,8-tetramethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl) Ester d-alpha-Tocopherol succinate(E) a-Tocopheryl Hydrogen Succinate Butanedioic acid, mono[(2R)-3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-yl] ester 4-Oxo-4-({(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-chromen-6-yl}oxy)butanoic acid a-Tocopherol Hemisuccinate Vitamin E Succinate MFCD00072055 Covitol 1210 (+)-a-Tocopheryl Succinate |
Description | D-α-Tocopherol Succinate (Vitamin E succinate) is an antioxidant tocopherol and a salt form of vitamin E. D-α-Tocopherol Succinate inhibits Cisplatin (HY-17394)-induced cytotoxicity. D-α-Tocopherol Succinate can be used for the research of cancer[1][2]. |
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Related Catalog | |
In Vitro | D-α-Tocopherol Succinate (1-20 μM; 24 hours) shows cytotoxicity to HEI-OC1 cells[1]. D-α-Tocopherol Succinate (10 μM; 48 hours) protects HEI-OC1 cells against cisplatin-induced ototoxicity and inhibits caspase-3 activity[1]. D-α-Tocopherol Succinate (0-50 μM; 18 hours) shows cytotoxicity to TC-1 tumor cells[2]. Cell Cytotoxicity Assay[1] Cell Line: HEI-OC1 cell line Concentration: 1-20 μM Incubation Time: 24 hours Result: Significantly induced cytotoxicity at a concentration of 20 μM and showed a higher cytotoxicity potency compared with 10 μM. Cell Viability Assay[1] Cell Line: HEI-OC1 cell line Concentration: 10 μM Incubation Time: 48 hours Result: Increased cisplatin-induced cell population. Inhibited cisplatin-induced necrotic, ROS production and late apoptosis. Decreased cleaved PARP and inhibited the expression of caspase-3 which related to cisplatin-induced apoptosis. Cell Cytotoxicity Assay[2] Cell Line: TC-1 tumor cells Concentration: 0, 25 and 50 μM Incubation Time: 18 hours Result: Dose-dependently showed cytotoxic and induced a higher percentage of necrotic TC-1 cells as opposed to apoptotic cells. |
In Vivo | D-α-Tocopherol Succinate (1-2 mg/kg; i.p. three times at 2 day intervals from TC-1 tumor cells injection for 10 days to 14 days) shows antitumor effects to mice with TC-1 tumor[2]. Animal Model: Six- to eight-week-old female C57BL/6 mice with TC-1 tumor cells[2] Dosage: 1 and 2 mg/kg Administration: Intraperitoneal injection; 1 and 2 mg/kg three times at 2 day intervals; from TC-1 tumor cells injection for 10 days to 14 days Result: Dreased the tumor volume, especially with a dose of 2 mg/kg. |
References |
Density | 1.0±0.1 g/cm3 |
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Boiling Point | 625.8±55.0 °C at 760 mmHg |
Melting Point | ~76 °C(lit.) |
Molecular Formula | C33H54O5 |
Molecular Weight | 530.779 |
Flash Point | 187.0±25.0 °C |
Exact Mass | 530.397095 |
PSA | 72.83000 |
LogP | 11.88 |
Vapour Pressure | 0.0±1.9 mmHg at 25°C |
Index of Refraction | 1.498 |
Storage condition | 2-8°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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Hazard Codes | Xi |
RIDADR | NONH for all modes of transport |
WGK Germany | 1 |
RTECS | EJ9984000 |
~84% 4345-03-3 |
Literature: Redoules, Daniel; Bordat, Pascal; Perie, Jean-Jacques Patent: US2004/236098 A1, 2004 ; Location in patent: Page 4 ; |
~72% 4345-03-3 |
Literature: Redoules, Daniel; Bordat, Pascal; Perie, Jean-Jacques Patent: US2004/236098 A1, 2004 ; Location in patent: Page 4 ; |
~% 4345-03-3 |
Literature: US2486539 , ; |
~% 4345-03-3 |
Literature: US2486539 , ; |
Precursor 5 | |
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DownStream 0 |